Microglia are the intrinsic immune cells of the brain and express chemokine and cytokine
receptors that interact with the peripheral immune cells. Recent studies have indicated that …

Multiple sclerosis is increasingly being recognized as a neurodegenerative disease that is
triggered by inflammatory attack of the CNS. As yet there is no satisfactory treatment. Using …

Activated microglia may be detrimental to neuronal survival in a number of neurodegenerative
diseases. Thus, strategies that reduce microglial neurotoxicity may have therapeutic …

Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia, the
brain's resident phagocyte, are pivotal for the immune response observed in AD. Microglia …

A reduction in microglial activation and subsequent neurotoxicity may prove critical for
neuroprotection in neurodegenerative diseases. We examined the expression and functionality of …

Microglia, the resident macrophage of the brain, can release substances that aid neuronal
development, differentiation and survival. We have investigated the effects of non‐activated …

Rare variants in TREM2 cause susceptibility to late-onset Alzheimer's disease. Here we use
microarray-based expression data generated from 101 neuropathologically normal …

Recently, we reported oligoadenylate synthetase 1 (OAS1) contributed to the risk of Alzheimer’s
disease, by its enrichment in transcriptional networks expressed by microglia. However, …

Dysfunction of microglia, the brain's immune cells, is linked to neurodegeneration.
Homozygous missense mutations in TREM2 cause Nasu-Hakola disease (NHD), an early-onset …

Background The R47H variant of the Triggering Receptor Expressed on Myeloid cells 2 (TREM2)
significantly increases the risk for late onset Alzheimer’s disease. Mouse models …