Gene delivery vectors based on adeno-associated viruses (AAV) have exhibited promise in
both preclinical disease models and human clinical trials for numerous disease targets, …

Optogenetic therapies for vision restoration aim to confer intrinsic light sensitivity to retinal
ganglion cells when photoreceptors have degenerated and light sensitivity has been …

Stem cell-based transplantation therapies offer hope for currently untreatable retinal degenerations;
however, preclinical progress has been largely confined to rodent models. Here, we …

All retina-based vision restoration approaches rely on the assumption that photoreceptor
loss does not preclude reactivation of the remaining retinal architecture. Whether extended …

Here we demonstrate the application of a method that could accelerate the development of
novel therapies by allowing direct and repeatable visualization of cellular function in the …

The primate fovea is specialized for high acuity chromatic vision, with the highest density of
cone photoreceptors and a disproportionately large representation in visual cortex. The …

Purpose: The development of new approaches to human vision restoration could be greatly
accelerated with the use of nonhuman primate models; however, there is a paucity of …

Insertion of light-gated channels into inner retina neurons restores neural light responses,
light evoked potentials, visual optomotor responses and visually-guided maze behavior in …

The primate fovea is specialized for high acuity chromatic vision, with the highest density of
cone photoreceptors and a disproportionately large representation in visual cortex. The …

Adaptive optics retinal imaging of fluorescent calcium indicators is a minimally invasive
method used to study retinal physiology over extended periods of time. It has potential for …