The spread of protein aggregates during disease progression is a common theme underlying
many neurodegenerative diseases. The microtubule-associated protein tau has a central …

Nonmembrane-bound organelles that behave like liquid droplets are widespread among
eukaryotic cells. Their dysregulation appears to be a critical step in several neurodegenerative …

Viral protein homeostasis depends entirely on the machinery of the infected cell. Accordingly,
viruses can illuminate the interplay between cellular proteostasis components and their …

The COVID-19 pandemic has created massive demand for widespread, distributed tools for
detecting SARS-CoV-2 genetic material. The hurdles to scalable testing include reagent and …

The misfolding and accumulation of tau protein into intracellular aggregates known as
neurofibrillary tangles is a pathological hallmark of neurodegenerative diseases such as …

Proteins with Bcl2-associated anthanogene (BAG) domains act as nucleotide exchange
factors (NEFs) for the molecular chaperone heat shock protein 70 (Hsp70). There are six BAG …

Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in
cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby …

Small heat shock proteins (sHsps) are a family of ATP-independent molecular chaperones
that are important for binding and stabilizing unfolded proteins. In this task, the sHsps have …

A network of molecular chaperones is known to bind proteins (‘clients’) and balance their
folding, function and turnover. However, it is often unclear which chaperones are critical for …

10.7554/eLife.42571.001 The mechanism that leads to liquid-liquid phase separation (LLPS)
of the tau protein, whose pathological aggregation is implicated in neurodegenerative …