Beyond their role as a cellular powerhouse, mitochondria are emerging as integral players
in molecular signaling and cell fate determination through reactive oxygen species (ROS). …

Prolonged mitochondrial permeability transition pore (MPTP) opening results in mitochondrial
energetic dysfunction, organelle swelling, rupture, and typically a type of necrotic cell …

AT→ G transversion at nt 8993 in mitochondrial DNA of MTATP6 (encoding ATPase 6 of
complex V of the respiratory chain) causes impaired mitochondrial ATP synthesis in two related …

Mitochondrial dysfunction and dysregulation of apoptosis are implicated in many diseases
such as cancer and neurodegeneration. We investigate here the role of respiratory chain (RC…

In the heart, augmented Ca 2+ fluxing drives contractility and ATP generation through
mitochondrial Ca 2+ loading. Pathologic mitochondrial Ca 2+ overload with ischemic injury …

The role of mitochondrial dysfunction in cancer has been a subject of great interest and
much ongoing investigation. Although most cancer cells harbor somatic mutations in …

10.7554/eLife.00772.001 A critical event in ischemia-based cell death is the opening of the
mitochondrial permeability transition pore (MPTP). However, the molecular identity of the …

In the past decade, the genetic causes underlying familial forms of many neurodegenerative
disorders, such as Huntington's disease, Parkinson's disease, Alzheimer's disease, …

Rationale: Mitochondria produce ATP, especially critical for survival of highly aerobic cells,
such as cardiac myocytes. Conversely, opening of mitochondrial high-conductance and long-…

Copper is required for the activity of cytochrome c oxidase (COX), the terminal electron-accepting
complex of the mitochondrial respiratory chain. The likely source of copper used for …