Complex biopharmaceuticals, such as recombinant blood coagulation factors, are addressing
critical medical needs and represent a growing multibillion‐dollar market. For commercial …

The diversity of autoimmune responses poses a formidable challenge to the development of
antigen-specific tolerizing therapy. We developed 'myelin proteome' microarrays to profile …

OBJECTIVES: To explore candidate prognostic and predictive biomarkers identified in
retrospective observational studies (interleukin-6, C-reactive protein, lactate dehydrogenase, …

Both common and rare genetic variants of laccase domain-containing 1 (LACC1, previously
C13orf31) are associated with inflammatory bowel disease, leprosy, Behcet disease, and …

The benefits of large-scale genetic studies for healthcare of the populations studied are well
documented, but these genetic studies have traditionally ignored people from some parts of …

Background Idiopathic pulmonary fibrosis (IPF) risk has a strong genetic component. Studies
have implicated variations at several loci, including TERT, surfactant genes, and a single …

Background Maturity-onset diabetes of the young (MODY) is an early-onset, autosomal
dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can transform …

Age is the main risk factor for sporadic Alzheimer’s disease. Yet, cognitive decline in aged
rodents has been less well studied, possibly due to concomitant changes in sensory or …

Background The Janus kinase (JAK) pathway mediates the activity of many asthma-relevant
cytokines, including IL-4 and IL-13. GDC-0214 is a potent, inhaled, small-molecule JAK …

Background Large sample sets of whole genome sequencing with deep coverage are being
generated, however assembling datasets from different sources inevitably introduces batch …