[HTML][HTML] Leveraging allelic imbalance to refine fine-mapping for eQTL studies
Many disease risk loci identified in genome-wide association studies are present in non-coding
regions of the genome. Previous studies have found enrichment of expression …
regions of the genome. Previous studies have found enrichment of expression …
Discovering single nucleotide polymorphisms regulating human gene expression using allele specific expression from RNA-seq data
The study of the genetics of gene expression is of considerable importance to understanding
the nature of common, complex diseases. The most widely applied approach to identifying …
the nature of common, complex diseases. The most widely applied approach to identifying …
Using genomic annotations increases statistical power to detect eGenes
Motivation: Expression quantitative trait loci (eQTLs) are genetic variants that affect gene
expression. In eQTL studies, one important task is to find eGenes or genes whose expressions …
expression. In eQTL studies, one important task is to find eGenes or genes whose expressions …
Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach
…, C Koumenis, E Diffenderfer, JW Zou - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. A physicochemical model built on the radiochemical kinetic theory was recently
proposed in (Labarbe et al 2020) to explain the FLASH effect. We performed extensive …
proposed in (Labarbe et al 2020) to explain the FLASH effect. We performed extensive …
Genome-Wide Association Study in two cohorts from a multi-generational mouse advanced intercross line highlights the difficulty of replication due to study-specific …
…, CL St. Pierre, NM Gonzales, J Zou… - G3: Genes …, 2020 - academic.oup.com
There has been extensive discussion of the “Replication Crisis” in many fields, including
genome-wide association studies (GWAS). We explored replication in a mouse model using an …
genome-wide association studies (GWAS). We explored replication in a mouse model using an …
Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility
Combining samples for genetic association is standard practice in human genetic analysis
of complex traits, but is rarely undertaken in rodent genetics. Here, using 23 phenotypes and …
of complex traits, but is rarely undertaken in rodent genetics. Here, using 23 phenotypes and …
Accurate modeling of replication rates in genome-wide association studies by accounting for Winner's Curse and study-specific heterogeneity
J Zou, J Zhou, S Faller, RP Brown, SS Sankararaman… - G3, 2022 - academic.oup.com
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with complex human traits, but only a fraction of variants identified in discovery …
associated with complex human traits, but only a fraction of variants identified in discovery …
Leveraging allele-specific expression to refine fine-mapping for eQTL studies
Many disease risk loci identified in genome-wide association studies are present in non-coding
regions of the genome. It is hypothesized that these variants affect complex traits by …
regions of the genome. It is hypothesized that these variants affect complex traits by …
Acute hospitalizations after proton beam therapy (PBT) versus intensity-modulated radiotherapy (IMRT) for locally advanced non–small-cell lung cancer (LA-NSCLC) …
…, A Doucette, Y Xiao, K Teo, S O'Reilly, JW Zou… - 2023 - ascopubs.org
8573 Background: Prior work found that PBT is associated with fewer acute hospitalizations
compared to photons for a variety of cancers. Patients (pts) with LA-NSCLC treated with …
compared to photons for a variety of cancers. Patients (pts) with LA-NSCLC treated with …
EA8185: Phase II study of bladder-sparing chemoradiation (chemoRT) with durvalumab in clinical stage III, node-positive urothelial carcinoma (INSPIRE), ECOG …
TPS500 Background: Patients [pts] withlymph node positive (LN+), non-metastatic bladder
cancer (BC) have a better prognosis than those with metastatic (M1) disease. However, this …
cancer (BC) have a better prognosis than those with metastatic (M1) disease. However, this …