[HTML][HTML] Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study
K Sun, J Chen, C Viboud - The Lancet Digital Health, 2020 - thelancet.com
Background As the outbreak of coronavirus disease 2019 (COVID-19) progresses, epidemiological
data are needed to guide situational awareness and intervention strategies. Here we …
data are needed to guide situational awareness and intervention strategies. Here we …
Exercise‐based cardiac rehabilitation for coronary heart disease
BS Heran, JMH Chen, S Ebrahim… - Cochrane database …, 2011 - cochranelibrary.com
Background The burden of coronary heart disease (CHD) worldwide is one of great concern
to patients and healthcare agencies alike. Exercise‐based cardiac rehabilitation aims to …
to patients and healthcare agencies alike. Exercise‐based cardiac rehabilitation aims to …
Estimation of excess deaths associated with the COVID-19 pandemic in the United States, March to May 2020
DM Weinberger, J Chen, T Cohen… - JAMA internal …, 2020 - jamanetwork.com
Importance Efforts to track the severity and public health impact of coronavirus disease
2019 (COVID-19) in the United States have been hampered by state-level differences in …
2019 (COVID-19) in the United States have been hampered by state-level differences in …
[PDF][PDF] Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens
Genetic screens help infer gene function in mammalian cells, but it has remained difficult to
assay complex phenotypes—such as transcriptional profiles—at scale. Here, we develop …
assay complex phenotypes—such as transcriptional profiles—at scale. Here, we develop …
Local regulation of gene expression by lncRNA promoters, transcription and splicing
Mammalian genomes are pervasively transcribed 1 , 2 to produce thousands of long non-coding
RNAs (lncRNAs) 3 , 4 . A few of these lncRNAs have been shown to recruit regulatory …
RNAs (lncRNAs) 3 , 4 . A few of these lncRNAs have been shown to recruit regulatory …
[PDF][PDF] Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming
Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying developmental …
major challenge. Here, we introduce Waddington-OT, an approach for studying developmental …
The NORAD lncRNA assembles a topoisomerase complex critical for genome stability
The human genome contains thousands of long non-coding RNAs 1 , but specific biological
functions and biochemical mechanisms have been discovered for only about a dozen 2 , 3 , …
functions and biochemical mechanisms have been discovered for only about a dozen 2 , 3 , …
Mechanism of ene reactions of singlet oxygen. A two-step no-intermediate mechanism
The mechanism of the ene reaction of singlet ( 1 Δ g ) oxygen with simple alkenes is
investigated by a combination of experimental isotope effects and several levels of theoretical …
investigated by a combination of experimental isotope effects and several levels of theoretical …
B cells in early and chronic HIV infection: evidence for preservation of immune function associated with early initiation of antiretroviral therapy
…, CM Buckner, J Ho, W Wang, J Chen… - Blood, The Journal …, 2010 - ashpublications.org
Abstract Characterization of lymphocytes including B cells during early versus chronic HIV
infection is important for understanding the impact of chronic viremia on immune cell function. …
infection is important for understanding the impact of chronic viremia on immune cell function. …
Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5
Rationale: Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for
cardiac regeneration. However, the key determinants involved in this process are unknown. …
cardiac regeneration. However, the key determinants involved in this process are unknown. …