The human immune system has evolved in the context of our colonisation by bacteria, viruses,
fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears …

Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common
health and economic problem worldwide, and one of the major risk factors for developing …

The immunomodulatory actions of parasitic helminth excretory-secretory (ES) products that
serendipitously protect against development of chronic inflammatory disorders are well …

Improvements in hygiene and health management have driven significant increases in human
lifespan over the last 50 years. Frustratingly however, this extension of lifespan has not …

One of the most rapidly increasing human public health problems is obesity, whose sequelae
like type-2 diabetes, represent continuously worsening, life-long conditions. Over the last …

Mice develop pathology in the lungs as they age and this may be accelerated by a high calorie
diet (HCD). ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae …

Despite significant increases in human lifespan over the last century, adoption of high calorie
diets (HCD) has driven global increases in type-2 diabetes, obesity and cardiovascular …

The recent extension of human lifespan has not been matched by equivalent improvements
in late-life health due to the global pandemic in type-2 diabetes, obesity and cardiovascular …

Objectives We have previously shown mitogen-activated protein kinase phosphatase 2 (MKP-2)
to be a key regulator of proinflammatory cytokines in macrophages. In the study …

The functional migration of immune cells during Leishmania infection is imperative for the
activation of a protective immune response. In particular, migration of dendritic cells (DCs) …