Nanoparticles with dense poly (ethylene glycol) coatings with near neutral charge are maximally transported across lymphatics and to the lymph nodes

J McCright, C Skeen, J Yarmovsky, K Maisel - Acta biomaterialia, 2022 - Elsevier
Lymphatic vessels have recently been shown to effectively deliver immune modulatory
therapies to the lymph nodes, which enhances their therapeutic efficacy. Prior work has shown …

[HTML][HTML] Targeting lymphatics for nanoparticle drug delivery

J McCright, R Naiknavare, J Yarmovsky… - Frontiers in …, 2022 - frontiersin.org
The lymphatics transport material from peripheral tissues to lymph nodes, where immune
responses are formed, before being transported into systemic circulation. With key roles in …

Para-and transcellular transport kinetics of nanoparticles across lymphatic endothelial cells

J McCright, J Yarmovsky, K Maisel - Molecular Pharmaceutics, 2023 - ACS Publications
Lymphatic vessels have received significant attention as drug delivery targets, as they shuttle
materials from peripheral tissues to the lymph nodes, where adaptive immunity is formed. …

Dense poly (ethylene glycol) coatings maximize nanoparticle transport across lymphatic endothelial cells and accumulate in the skindraining lymph nodes

J McCright, C Skeen, J Yarmovsky, K Maisel - bioRxiv, 2020 - biorxiv.org
Lymphatic vessels have recently been shown to effectively deliver immune modulatory
therapies to the lymph nodes, which enhances their therapeutic efficacy. Prior work has shown …

[PDF][PDF] Engineering nanoparticle surface chemistry to maximize lymph node delivery via lymphatic vessels

J McCright, C Skeen, J Yarmovsky, K Maisel - abstracts.biomaterials.org
Methods: Fluorescently labeled, 100 nm carboxyl functionalized polystyrene (PS) NPs were
coated with multi-functional polyethylene glycol (PEG) using NHS-EDC chemistry and …

A Computational Model For Nanoparticle Delivery Across Lymphatics

J Yarmovsky - 2021 - drum.lib.umd.edu
In order to increase the efficacy and reduce the side effects of immunotherapies, immune-modulating
drugs should be delivered directly to secondary lymphoid organs, such as lymph …

[HTML][HTML] Month: April 2022

H Polin - theyweresoldiers.com
This is the third (of four) posts presenting photographs and biographical records of American
Jewish soldiers from the state of Pennsylvania who served in the First World War. The …

[HTML][HTML] Category: First World War

IS CLAIR - theyweresoldiers.com
In several prior posts, I’ve presented an overview of the military service of American Jewish
soldiers during the First World War, through a general overview of the military service of …

Design and synthesis of biologically inspired biocompatible various polymeric magnetic nanoparticles for imaging and biomedical applications

R AboGabal, D Shokeir, AH Oraby - Nano-Structures & Nano-Objects, 2023 - Elsevier
Highly monodispersed magnetite nanoparticles with controlled particle size and surface
coatings have been successfully synthesized as a model system to investigate the effect of the …

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R against Perpetuities - Australian Law Journal, 1930 - HeinOnline
Yarmovsky had carried on business as a manufacturer of ladies' mantles and costumes
since 1917 and had from time to time carried on such business in various premises. He had not …