While footprinting analysis of ATAC-seq data can theoretically enable investigation of
transcription factor (TF) binding, the lack of a computational tool able to conduct different levels of …

Formation and segregation of cell lineages forming the heart have been studied extensively
but the underlying gene regulatory networks and epigenetic changes driving cell fate …

Tubulogenesis is essential for the formation and function of internal organs. One such organ
is the trachea, which allows gas exchange between the external environment and the lungs. …

Abstract The annotation of genomic ranges of interest represents a recurring task for
bioinformatics analyses. These ranges can originate from various sources, including peaks called …

Damage-induced fibrotic scarring limits tissue regeneration in mammals and is a leading
cause of morbidity. In contrast, species like zebrafish can regenerate damaged tissues without …

The long-chain fatty acid receptor FFAR1 is highly expressed in pancreatic β-cells. Synthetic
FFAR1 agonists can be used as antidiabetic drugs to promote glucose-stimulated insulin …

Background: The angiogenic function of endothelial cells is regulated by numerous mechanisms,
but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out …

Background Notophthalmus viridescens, an urodelian amphibian, represents an excellent
model organism to study regenerative processes, but mechanistic insights into molecular …

G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but
heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly …

The identity of tumor-initiating cells in many cancer types is unknown. Tumors often express
genes associated with embryonic development, although the contributions of zygotic …