The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic
architecture and biology of heart, lung, blood and sleep disorders, with the ultimate goal of …

Only mammals have relinquished parthenogenesis, a means of producing descendants solely
from maternal germ cells. Mouse parthenogenetic embryos die by day 10 of gestation 1 , …

All cancers harbor molecular alterations in their genomes. The transcriptional consequences
of these somatic mutations have not yet been comprehensively explored in lung cancer. …

Heat shock protein 70 (HSP70) has been shown to act as an inhibitor of apoptosis. We have
also observed an inhibitory effect of HSP70 on apoptotic cell death both in preheated U937 …

The identification of the molecular events that drive cancer transformation is essential to the
development of targeted agents that improve the clinical outcome of lung cancer. Many …

The nucleotide sequence was determined for the genome of Xanthomonas oryzae pathovar
oryzae (Xoo) KACC10331, a bacterium that causes bacterial blight in rice (Oryza sativa L.). …

Recent advances in sequencing technologies have initiated an era of personal genome
sequences. To date, human genome sequences have been reported for individuals with …

Despite considerable excitement over the potential functional significance of copy-number
variants (CNVs), we still lack knowledge of the fine-scale architecture of the large majority of …

Hsp72, a major inducible member of the heat shock protein family, can protect cells against
many cellular stresses including heat shock. In our present study, we observed that …

To elucidate the genetics of coronary artery disease (CAD) in the Japanese population, we
conducted a large-scale genome-wide association study of 168,228 individuals of Japanese …