The elegance of animal body plans derives from an intimate connection between function and
form, which during organ formation is linked to patterning and growth. Yet, how patterning …

Decoding how tissue properties emerge across multiple spatial and temporal scales from
the integration of local signals is a grand challenge in quantitative biology. For example, the …

Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of
mortality; however, mechanisms governing adaptation to the brain microenvironment remain …

The robust specification of organ development depends on coordinated cell-cell communication.
This process requires signal integration among multiple pathways, relying on second …

Mitotic rounding during cell division is critical for preventing daughter cells from inheriting an
abnormal number of chromosomes, a condition that occurs frequently in cancer cells. Cells …

The question of how the physical dimensions of animal organs are specified has long
fascinated both experimentalists and computational scientists working in the field of …

Mechanical forces are critical but poorly understood inputs for organogenesis and wound
healing. Calcium ions (Ca 2+ ) are critical second messengers in cells for integrating …

Two-dimensional patterning of the follicular epithelium in Drosophila oogenesis is required
for the formation of three-dimensional eggshell structures. Our analysis of a large number of …

Potassium ion (K+) channels have been recently found to play a critical role in cancer biology.
Despite that pharmacologic manipulation of ion channels is recognized as an important …

Epithelial sheets define organ architecture during development. Here, we employed an iterative
multiscale computational modeling and quantitative experimental approach to decouple …