Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Importance Tourette syndrome (TS) is characterized by high rates of psychiatric comorbidity;
however, few studies have fully characterized these comorbidities. Furthermore, most …

Obsessive-compulsive disorder (OCD) is a common, debilitating neuropsychiatric illness
with complex genetic etiology. The International OCD Foundation Genetics Collaborative (…

Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder that
is characterized by several motor and phonic tics. Tics usually develop before 10 years of …

The aim of this study was to refine the population prevalence estimate of Tourette Syndrome
(TS) in children and to investigate potential sources of heterogeneity in previously …

The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …

Objective: Tourette’s syndrome is polygenic and highly heritable. Genome-wide association
study (GWAS) approaches are useful for interrogating the genetic architecture and …

Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial
recurrence rates among neuropsychiatric diseases with complex inheritance. However, the …

Context: Obsessive‐Compulsive Disorder (OCD) is a debilitating illness with putative
glutamatergic abnormalities. Two separate proximal haplotypes in the glutamate transporter gene, …

OBJECTIVES: This article summarizes and evaluates recent advances in the genetics of
Gilles de la Tourette syndrome (GTS). METHODS: This is a review of recent literature focusing …