Human fibroblasts infected with human cytomegalovirus (HCMV) were more viable than
uninfected cells during glucose starvation, suggesting that an alternate carbon source was used…

The JNK signaling cascade is critical for cellular responses to a variety of environmental
and cellular stimuli. Although gene expression aspects of JNK signal transduction are well …

Large scale expansion of human mesenchymal stem cells (MSCs) is routinely performed for
clinical therapy. In contrast, developing protocols for large scale expansion of primary …

To build upon recent findings that mitochondrial JNK signaling is inhibited by selectively
blocking the interaction between JNK and Sab, we utilized a cell-permeable peptide to …

There are currently no drugs to treat neurodegeneration in Parkinson’s disease (PD), and
all existing medications only treat symptoms, lose efficacy over time, and produce untoward …

Mitochondria are highly integrated organelles that are crucial to cell adaptation and mitigating
adverse physiology. Recent studies demonstrate that fundamental signal transduction …

Because oxidative stress and mitochondrial dysfunction are well known contributors to
Parkinson disease (PD), we set out to investigate the role mitochondrial JNK plays in the etiology …

Bacterial DNA gyrase, a type IIA DNA topoisomerase that plays an essential role in bacterial
DNA replication and transcription, is a clinically validated target for discovering and …

In this work, we show the advantages of label-free, tridimensional mass spectrometry imaging
using dual beam analysis (25 keV Bi 3 + ) and depth profiling (20 keV with a distribution …

Given the significant body of data supporting an essential role for c-jun-N-terminal kinase (JNK)
in neurodegenerative disorders, we set out to develop highly selective JNK inhibitors …