The global distribution and burden of dengue

…, GRW Wint, CP Simmons, TW Scott, JJ Farrar… - Nature, 2013 - nature.com
Dengue is a systemic viral infection transmitted between humans by Aedes mosquitoes 1 .
For some patients, dengue is a life-threatening illness 2 . There are currently no licensed …

[HTML][HTML] Dengue: a continuing global threat

…, SB Halstead, H Artsob, P Buchy, J Farrar… - Nature reviews …, 2010 - nature.com
Dengue fever and dengue haemorrhagic fever are important arthropod-borne viral diseases.
Each year, there are ∼50 million dengue infections and ∼500,000 individuals are …

[HTML][HTML] Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia

…, Y Guan, JSM Peiris, NT Chinh, TT Hien, J Farrar - Nature medicine, 2006 - nature.com
Avian influenza A (H5N1) viruses cause severe disease in humans 1 , 2 , but the basis for
their virulence remains unclear. In vitro and animal studies indicate that high and …

[HTML][HTML] Dengue

CP Simmons, JJ Farrar… - New England Journal …, 2012 - Mass Medical Soc
There are an estimated 50 million infections per year with the dengue virus, which is
transmitted primarily by urban-adapted Aedes aegypti mosquitoes. This review summarizes …

Into the eye of the cytokine storm

…, MJ Korth, CP Simmons, J Farrar… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community alike,
and while the general notion of an excessive or uncontrolled release of proinflammatory …

[PDF][PDF] The origins of SARS-CoV-2: A critical review

…, WS Barclay, MF Boni, PC Doherty, J Farrar… - Cell, 2021 - cell.com
Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus
in December 2019 in Wuhan, China, there has been intense interest in understanding how …

[HTML][HTML] Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults

…, NJ White, TT Hien, JJ Farrar - … England Journal of …, 2004 - Mass Medical Soc
Background Tuberculous meningitis kills or disables more than half of those affected with the
disease. Previous studies have been too small to determine whether adjunctive treatment …

[HTML][HTML] Avian influenza A (H5N1) in 10 patients in Vietnam

…, P Cheng, W Lim, P Horby, J Farrar - … England Journal of …, 2004 - Mass Medical Soc
Background Recent outbreaks of avian influenza A (H5N1) in poultry throughout Asia have
had major economic and health repercussions. Human infections with this virus were …

[HTML][HTML] Oseltamivir resistance during treatment of influenza A (H5N1) infection

…, Y Guan, JSM Peiris, TT Hien, J Farrar - New england journal …, 2005 - Mass Medical Soc
<p id="p001">Influenza A (H5N1) virus with an amino acid substitution in neuraminidase
conferring high-level resistance to oseltamivir was isolated from two of eight Vietnamese …

[HTML][HTML] Effect of Delta variant on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

…, T House, J Hay, JI Bell, JN Newton, J Farrar… - Nature medicine, 2021 - nature.com
The effectiveness of the BNT162b2 and ChAdOx1 vaccines against new severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections requires continuous re-evaluation, …