Zoonotic transmission of coronaviruses poses an ongoing threat to human populations.
Endemic outbreaks of swine acute diarrhea syndrome coronavirus (SADS-CoV) have caused …

Background Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral
arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15–…

Intestinal stem cell (ISC) plasticity is thought to be regulated by broadly permissive chromatin
shared between ISCs and their progeny. Here, we have used a Sox9 EGFP reporter to …

The COVID-19 pandemic, caused by SARS-CoV-2, continues to impact global health regarding
both morbidity and mortality. Although SARS-CoV-2 primarily causes acute respiratory …

Chronic limb-threatening ischemia (CLTI), representing the end-stage of peripheral arterial
disease (PAD), is associated with a one-year limb amputation rate of ∼15-20% and …

Animal models have historically been poor preclinical predictors of gastrointestinal (GI)
directed therapeutic efficacy and drug-induced GI toxicity. Human stem and primary cell-derived …

Chromatin is central to cellular identity and is remodeled as stem cells differentiate and
acquire mature cell fates. In the adult intestinal epithelium, functional plasticity facilitates de-…

The intestinal microbiome is a critical determinant of human health. Alterations in its composition
have been correlated with chronic disorders, such as obesity and inflammatory bowel …

Aging is associated with increased morbidity arising from a range of tissue dysfunctions. A
common denominator of age-associated frailty is increased baseline inflammation, called …

The core of intermediary metabolism in autotrophs is the citric acid cycle. In a certain group
of chemoautotrophs, the reductive citric acid cycle is an engine of synthesis, taking in CO 2 …