The ability of the immune system to identify and destroy nascent tumors, and to thereby
function as a primary defense against cancer, has been debated for many decades. Recent …

The capacity of immunity to control and shape cancer, that is, cancer immunoediting, is the
result of three processes 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 that function either independently or in …

The emergence of jawed vertebrates (gnathostomes) from jawless vertebrates was accompanied
by major morphological and physiological innovations, such as hinged jaws, paired …

This brief review discusses the role of the immune system in tumor development, covering a
history of cancer immunity and a summary of the concept of cancer immunoediting, …

Myeloproliferative syndromes (MPS) are a heterogeneous subclass of nonlymphoid hematopoietic
neoplasms which are considered to be intrinsic to hematopoietic cells. The causes of …

CD4+ CD25+ regulatory T cells (Treg) that suppress T cell-mediated immune responses
may also regulate other arms of an effective immune response. In particular, in this study we …

Here we report the effects of loss of the Toll-like receptor-associated signaling adaptor
myeloid-differentiation factor 88 (MyD88) on tumor induction in two distinct mouse models of …

This study demonstrates that type I IFNs are an early and critical regulator of NK cell numbers,
activation, and antitumor activity. Using both IFNAR1-and IFNAR2-deficient mice, as well …

The activation NKG2D receptor has been shown to play an important role in the control of
experimental tumor growth and metastases expressing ligands for NKG2D; however, a …

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic
staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for …