[HTML][HTML] Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression

…, JS Stancill, I Smolders, V Goffin, N Binart, J Declercq… - Cell metabolism, 2014 - cell.com
The human growth hormone (hGH) minigene is frequently used in the derivation of transgenic
mouse lines to enhance transgene expression. Although this minigene is present in the …

PLAG1, the prototype of the PLAG gene family: versatility in tumour development

F Van Dyck, J Declercq, CV Braem… - International …, 2007 - spandidos-publications.com
Recent studies of human tumours as well as genetically engineered mouse tumour models
have established the importance and versatility of the PLAG1 oncogene in tumourigenesis. …

Targeted disruption of the murine Plag1 proto‐oncogene causes growth retardation and reduced fertility

K Hensen, C Braem, J Declercq… - Development …, 2004 - Wiley Online Library
The pleomorphic adenoma gene 1 (Plag1) proto‐oncogene encodes a transcription factor
and is implicated in human tumorigenesis via ectopic overexpression. No information is …

Equine allogeneic chondrogenic induced mesenchymal stem cells are an effective treatment for degenerative joint disease in horses

…, T Mariën, E Adriaensen, J Declercq… - Stem Cells and …, 2019 - liebertpub.com
Degenerative joint disease is one of the main causes of equine early retirement from pleasure
riding or a performance career. The disease is initially triggered by an abnormal loading …

[HTML][HTML] Metabolic and behavioural phenotypes in Nestin-Cre mice are caused by hypothalamic expression of human growth hormone

J Declercq, B Brouwers, VPEG Pruniau, P Stijnen… - PloS one, 2015 - journals.plos.org
The Nestin-Cre driver mouse line has mild hypopituitarism, reduced body weight, a
metabolic phenotype and reduced anxiety. Although several causes have been suggested, a …

Salivary Gland Tumors in Transgenic Mice with Targeted PLAG1 Proto-Oncogene Overexpression

J Declercq, F Van Dyck, CV Braem… - Cancer research, 2005 - AACR
Pleomorphic adenoma gene 1 (PLAG1) proto-oncogene overexpression is implicated in
various human neoplasias, including salivary gland pleomorphic adenomas. To further assess …

Upregulation of Igf and Wnt signalling associated genes in pleomorphic adenomas of the salivary glands in PLAG1 transgenic mice

J Declercq, F Van Dyck… - International …, 2008 - spandidos-publications.com
The Pleomorphic adenoma gene 1 (PLAG1) is involved in various human neoplasias, including
pleomorphic adenomas of the salivary glands. Moreover, the oncogenic role of PLAG1 …

[HTML][HTML] Tenogenically induced allogeneic peripheral blood mesenchymal stem cells in allogeneic platelet-rich plasma: 2-year follow-up after tendon or ligament …

…, B Seys, A Vandenberghe, J Declercq… - Frontiers in veterinary …, 2017 - frontiersin.org
Poor healing of tendon and ligament lesions often results in early retirement of sport horses.
Therefore, regenerative therapies are being explored as potentially promising treatment for …

[PDF][PDF] Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons

F Van Dyck, CV Braem, Z Chen, J Declercq, R Deckers… - Cell metabolism, 2007 - cell.com
Enterocytes assemble dietary lipids into chylomicron particles that are taken up by intestinal
lacteal vessels and peripheral tissues. Although chylomicrons are known to assemble in …

Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction

…, F Schuit, SF Lichtenthaler, JL Estall, J Declercq… - Diabetes, 2021 - Am Diabetes Assoc
FURIN is a proprotein convertase (PC) responsible for proteolytic activation of a wide array
of precursor proteins within the secretory pathway. It maps to the PRC1 locus, a type 2 …