Background The risk of recurrence of cardiovascular events among patients using aspirin (acetylsalicylic
acid) for secondary prevention of such events remains high. Persistent platelet …

BACKGROUND: Despite clopidogrel therapy, patients undergoing percutaneous coronary
intervention (PCI) with stenting are at risk of recurrent coronary events. This could be partly …

Von Willebrand's disease is the most common inherited bleeding disorder and is generally
transmitted as an autosomal dominant trait. It is mainly associated with mucosal bleeding and …

Background A positive family history of venous thrombosis may reflect the presence of genetic
risk factors. Once a risk factor has been identified, it is not known whether family history is …

Background: von Willebrand disease (VWD) is the most common inherited bleeding disorder
known in humans. Accurate and timely diagnosis presents numerous challenges. Objective…

BACKGROUND: The absolute risk of recurrences among patients using aspirin for prevention
of cardiovascular events remains high. Persistent platelet reactivity despite aspirin therapy …

Factor VIII: C levels show a familial clustering, which remains after adjustment for the influence
of vWF and blood group. 46 Analysis of familial aggregation of factor VIII levels 150 IU/dL …

Type 1 von Willebrand disease (VWD) is characterized by a personal and family history of
bleeding coincident with reduced levels of normal plasma von Willebrand factor (VWF). The …

Factor VIII activity (factor VIII:C) levels ≥150 IU/dl are associated with a 5- to 6-fold increased
risk of venous thrombosis compared to levels <100 IU/dl, and fibrinogen levels ≥5.0 g/l …

Weibel-Palade bodies (WPBs) are elongated secretory organelles specific to endothelial
cells that contain von Willebrand factor (VWF) and a variety of other proteins that contribute to …