Many microRNAs (miRNAs) are encoded by small gene families. In a third of all conserved
Arabidopsis miRNA families, members vary at two or more nucleotide positions. We have …

… Author links open overlay panel Rime Kerfah 1 2 3 6 , Michael J Plevin 4 , Remy Sounier
5 , Pierre Gans 1 2 3 , Jerome Boisbouvier 1 2 3 … Boisbouvier … Boisbouvier …

Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM
and NMR spectroscopy both provide structural information, but currently cryo-EM does …

XH/π interactions make important contributions to biomolecular structure and function. These
weakly polar interactions, involving π-system acceptor groups, are usually identified from …

Sometimes less is more: [13C1H3]methyl isotopomers can be biosynthetically incorporated
specifically into the pro-S methyl groups of leucine and valine residues in large protein …

A strategy for the introduction of ( 1 H, 13 C-methyl)-alanine into perdeuterated proteins is
described. Specific protonation of alanine methyl groups to a level of 95% can be achieved by …

An optimized NMR experiment that combines the advantages of methyl-TROSY and
SOFAST-HMQC has been developed. It allows the recording of high quality methyl 1 H− 13 C …

Atomic-resolution information on the structure and dynamics of nucleic acids is essential for
a better understanding of the mechanistic basis of many cellular processes. NMR …

The function of proteins depends on their ability to sample a variety of states differing in
structure and free energy. Deciphering how the various thermally accessible conformations are …

Obtaining sequence-specific assignments remains a major bottleneck in solution NMR
investigations of supramolecular structure, dynamics and interactions. Here we demonstrate that …