Despite the success of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines, there remains a need for more prevention and treatment options for individuals …

We report unbiased metagenomic detection of chikungunya virus (CHIKV), Ebola virus (EBOV),
and hepatitis C virus (HCV) from four human blood samples by MinION nanopore …

Unbiased next-generation sequencing (NGS) approaches enable comprehensive pathogen
detection in the clinical microbiology laboratory and have numerous applications for public …

Frequent zoonotic transmission of hepatitis E virus (HEV) has been suspected, but data
supporting the animal origin of autochthonous cases are still sparse. We assessed the genetic …

Much attention has been focused on the role of the bacterial microbiome in human health,
but the virome is understudied. Although previously investigated in individuals with …

Background Nitidine is thought to be the main active ingredient in several traditional anti-malarial
remedies used in different parts of the world. The widespread use of these therapies …

The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health
threat and uncovered its association with severe diseases, including microcephaly. However, …

Background Primary amoebic meningoencephalitis (PAM) is a rare, often lethal, cause of
encephalitis, for which early diagnosis and prompt initiation of combination antimicrobials may …

Lyme disease is a tick-borne illness caused by the bacterium Borrelia burgdorferi , and
approximately 10 to 20% of patients report persistent symptoms lasting months to years despite …

Background Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease
characterized by frequent exacerbation phenotypes independent of disease stage. Increasing …