User profiles for Jerome D Swinny
 | Jerome SwinnyProfessor of Neuropharmacology, University of Portsmouth, United Kingdom Verified email at port.ac.uk Cited by 1873 |
[HTML][HTML] GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response
…, SG Mitchell, JD Swinny, JJ Lambert, D Belelli - Frontiers in …, 2015 - Elsevier
Regulation of hypothalamic–pituitary–adrenocortical (HPA) axis activity by stress is a
fundamental survival mechanism and HPA-dysfunction is implicated in psychiatric disorders. …
fundamental survival mechanism and HPA-dysfunction is implicated in psychiatric disorders. …
Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze‐fracture replica immunolabelling
Y Kasugai, JD Swinny, JDB Roberts… - European Journal of …, 2010 - Wiley Online Library
Hippocampal CA1 pyramidal cells, which receive γ‐aminobutyric acid (GABA)ergic input
from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABA A …
from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABA A …
Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic transmission in a mouse model of early-life adversity: relevance to neurosteroids and …
Adverse early-life experiences, such as poor maternal care, program an abnormal stress
response that may involve an altered balance between excitatory and inhibitory signals. Here, …
response that may involve an altered balance between excitatory and inhibitory signals. Here, …
[HTML][HTML] The Free-movement pattern Y-maze: A cross-species measure of working memory and executive function
Numerous neurodegenerative and psychiatric disorders are associated with deficits in
executive functions such as working memory and cognitive flexibility. Progress in developing …
executive functions such as working memory and cognitive flexibility. Progress in developing …
From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors
…, E Leppä, AM Linden, M Renzi, JD Swinny… - Nature …, 2007 - nature.com
In mammals, identifying the contribution of specific neurons or networks to behavior is a key
challenge. Here we describe an approach that facilitates this process by enabling the rapid …
challenge. Here we describe an approach that facilitates this process by enabling the rapid …
[HTML][HTML] A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling
The lateral habenula (LHb) has a key role in integrating a variety of neural circuits associated
with reward and aversive behaviors. There is limited information about how the different …
with reward and aversive behaviors. There is limited information about how the different …
[HTML][HTML] Absence of glial α-dystrobrevin causes abnormalities of the blood-brain barrier and progressive brain edema
…, M Frontczak-Baniewicz, JD Swinny… - Journal of Biological …, 2012 - ASBMB
The blood-brain barrier (BBB) plays a key role in maintaining brain functionality. Although
mammalian BBB is formed by endothelial cells, its function requires interactions between …
mammalian BBB is formed by endothelial cells, its function requires interactions between …
Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon
The enteric nervous system (ENS) provides the intrinsic neural control of the gastrointestinal
tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS …
tract (GIT) and regulates virtually all GI functions. Altered neuronal activity within the ENS …
Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants
Within the nucleus accumbens (NAc), synaptic GABA A receptors (GABA A Rs) mediate
phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to …
phasic inhibition of medium spiny neurons (MSNs) and influence behavioral responses to …
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter …
Aims Amyloid β‐oligomers (AβO) are potent modulators of Alzheimer's pathology, yet their
impact on one of the earliest brain regions to exhibit signs of the condition, the locus …
impact on one of the earliest brain regions to exhibit signs of the condition, the locus …