Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids. Nucleoid proteins
include not only factors involved in replication and transcription but also structural proteins …

Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19,
little is known about their mechanism(s) of action or effective dosing windows. We report …

How individual genes are regulated from a mitochondrial polycistronic transcript to have
variable expression remains an enigma. Here, through bisulfite sequencing and strand-specific …

Original research: Rationally targeted anti-VISTA antibody that blockades the CC’ loop region
can reverse VISTA immune suppression and remodel the immune microenvironment to …

It is tempting to assume that a gradual accumulation of damage ‘causes’ an organism to age,
but other biological processes present during the lifespan, whether ‘programmed’ or ‘…

Epigenetic modifications are critical determinants of cellular and developmental states.
Epigenetic changes, such as decreased H 3 K 27me3 histone methylation on insulin/ IGF 1 genes…

… JD Boyd-Kirkup is the chief scientific officer at and has ownership interest (including patents)
in Hummingbird Bioscience. No potential conflicts of interest were disclosed by the other …

… Ingram, Dipti Thakkar, Jerome D. Boyd-Kirkup. HMBD002, a novel neutralizing antibody
targeting a specific epitope on the co-inhibitory immune checkpoint receptor VISTA, displays …

With the rapidly increasing availability of high-throughput in situ hybridization images, how
to effectively analyze these images at high resolution for global patterns and testable …

Myeloid-derived suppressor cells (MDSCs) are a group of immature myeloid cells with potent
immune suppressive activity. Accumulation of pathologically activated MDSCs within the …