Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing
state called replicative senescence. It has been proposed that telomere shortening is the …

Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite
proliferation of human cells. A highly sensitive assay for measuring telomerase activity was …

Correspondence to S. Bacchetti. research in this field may render the information rapidly
outdated, we hope that the present survey of over 3500 tumour and control samples will aid …

Most normal mammalian cells have a finite lifespan 1 , thought to constitute a protective
mechanism against unlimited proliferation 2 , 3 , 4 . This phenomenon, called senescence, is …

Telomerase is a ribonucleoprotein that synthesizes telomere repeats onto chromosome
ends and is involved in maintaining telomere length in germline tissues and in immortal and …

The maintenance of chromosome termini, or telomeres, requires the action of the enzyme
telomerase, as conventional DNA poly-merases cannot fully replicate the ends of linear …

The telomere is a special functional complex at the end of linear eukaryotic chromosomes,
consisting of tandem repeat DNA sequences and associated proteins. It is essential for …

This is the first report describing up-regulation of telomerase activity in human normal cells.
Telomerase, a ribonucleoprotein enzyme, has been thought to be involved in maintaining …

Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have
limited capacity to divide, after which they become senescent — a phenomenon now known as …

We present evidence for the possible involvement of both the RB and p53 proteins in the
regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-…