User profiles for Jerzy Dziekan

Jerzy Michal Dziekan

The Walter and Eliza Hall Institute of Medical Research
Verified email at wehi.edu.au
Cited by 504

Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic …

…, S Nair, MMD White, J Dziekan… - Clinical infectious …, 2016 - academic.oup.com
Background. Deployment of mefloquine–artesunate (MAS3) on the Thailand–Myanmar border
has led to a sustained reduction in falciparum malaria, although antimalarial efficacy has …

Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay

JM Dziekan, H Yu, D Chen, L Dai, G Wirjanata… - Science translational …, 2019 - science.org
Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better resolved …

Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome

JM Dziekan, G Wirjanata, L Dai, KD Go, H Yu, YT Lim… - Nature protocols, 2020 - nature.com
Despite decades of research, little is known about the cellular targets and the mode of action
of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal …

Genomic, transcriptomic, and metabolomic analysis of Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti‐cancer metabolites

…, SK Lai, LK Yang, IT Beh, J Dziekan… - Journal of Integrative …, 2023 - Wiley Online Library
Plants accumulate a vast array of secondary metabolites, which constitute a natural resource
for pharmaceuticals. Oldenlandia corymbosa belongs to the Rubiaceae family, and has …

[PDF][PDF] Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

MP Wagner, P Formaglio, O Gorgette, JM Dziekan… - Cell Reports, 2022 - cell.com
The uptake and digestion of host hemoglobin by malaria parasites during blood-stage
growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation …

[HTML][HTML] Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the …

…, G Wirjanata, S Nayak, J Boentoro, JM Dziekan… - PLoS …, 2023 - journals.plos.org
Resistance of the human malaria parasites, Plasmodium falciparum, to artemisinins is now
fully established in Southeast Asia and is gradually emerging in Sub-Saharan Africa. …

[HTML][HTML] Identification and structural validation of purine nucleoside phosphorylase from Plasmodium falciparum as a target of MMV000848

Z Chung, J Lin, G Wirjanata, JM Dziekan… - Journal of Biological …, 2024 - ASBMB
About 247 million cases of malaria occurred in 2021 with Plasmodium falciparum
accounting for the majority of 619,000 deaths. In the absence of a widely available vaccine, …

Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors

I Dobrescu, E Hammam, JM Dziekan… - ACS Infectious …, 2023 - ACS Publications
Malaria drug resistance is hampering the fight against the deadliest parasitic disease
affecting over 200 million people worldwide. We recently developed quinoline-quinazoline-based …

FKBP35 secures ribosome homeostasis in Plasmodium falciparum

BT Thommen, JM Dziekan, F Achcar, S Tjia… - bioRxiv, 2022 - biorxiv.org
Plasmodium falciparum is the most virulent malaria parasite and accounts for the majority of
over 600’000 malaria-associated deaths annually. Parasites resistant to nearly all …

Genetic validation of PfFKBP35 as an antimalarial drug target

BT Thommen, JM Dziekan, F Achcar, S Tjia… - Elife, 2023 - elifesciences.org
Plasmodium falciparum accounts for the majority of over 600,000 malaria-associated deaths
annually. Parasites resistant to nearly all antimalarials have emerged and the need for …