Evidence for direct, gene‐mediated stable genetic transformation of plant cells of Nicotiana
tabacum is presented. A selectable hybrid gene comprising the protein coding region of the …

Eukaryotic genomes consist to a significant extent of retrotransposons that are suppressed
by host epigenetic mechanisms, preventing their uncontrolled propagation 1 , 2 . However, it …

In mammals, the DNA methyltransferase 1 (Dnmt1) faithfully copies the pattern of cytosine
methylation at CpG sites to the newly synthesized strand, and this is essential for epigenetic …

Plant epigenetics has recently gained unprecedented interest, not only as a subject of basic
research but also as a possible new source of beneficial traits for plant breeding. We …

Although the generation of transgenic plants is now routine, the integration of foreign genetic
information has so far been at random sites in the genome. We now present evidence for …

A large number of recent studies have demonstrated that many important aspects of plant
development are regulated by heritable changes in gene expression that do not involve …

Transgenerational epigenetic inheritance has been defined by the study of relatively few loci.
We examined a population of recombinant inbred lines with epigenetically mosaic …

Maintenance of CG methylation ( m CG) patterns is essential for chromatin-mediated epigenetic
regulation of transcription in plants and mammals. However, functional links between m …

Retrotransposons are mobile genetic elements that populate chromosomes, where the host
largely controls their activities 1 , 2 , 3 . In plants and mammals, retrotransposons are …

In mammals and plants, formation of heterochromatin is associated with hypermethylation of
DNA at CpG sites and histone H3 methylation at lysine 9. Previous studies have revealed …