A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis

…, A Luque-García, J García-Castillo… - … and cellular biology, 2009 - Taylor & Francis
HER2 is a tyrosine kinase receptor causally involved in cancer. A subgroup of breast cancer
patients with particularly poor clinical outcomes expresses a heterogeneous collection of …

Molecular cloning and expression analysis of tumor necrosis factor α from a marine fish reveal its constitutive expression and ubiquitous nature

J García-Castillo, P Pelegrín, V Mulero, J Meseguer - Immunogenetics, 2002 - Springer
The tumor necrosis factor α (TNF α) gene from the marine fish, gilthead seabream (Sparus
aurata L.), has been isolated by RT-PCR using degenerate primers designed against …

[PDF][PDF] PI3K/Akt cooperates with oncogenic notch by inducing nitric oxide-dependent inflammation

…, L García-López, I Gutierrez-Perez, J García-Castillo… - Cell reports, 2018 - cell.com
The PI3K/Akt signaling pathway, Notch, and other oncogenes cooperate in the induction of
aggressive cancers. Elucidating how the PI3K/Akt pathway facilitates tumorigenesis by other …

[HTML][HTML] Telomerase RNA-based aptamers restore defective myelopoiesis in congenital neutropenic syndromes

E Martínez-Balsalobre, J García-Castillo… - Nature …, 2023 - nature.com
Telomerase RNA (TERC) has a noncanonical function in myelopoiesis binding to a consensus
DNA binding sequence and attracting RNA polymerase II (RNA Pol II), thus facilitating …

Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1β following infection with Vibrio anguillarum

E Chaves-Pozo, P Pelegrín, J García-Castillo… - Cell and tissue …, 2004 - Springer
The fish immune response to Gram-negative bacteria is poorly understood. In this study, we
use a monoclonal antibody (mAb) specific to acidophilic granulocytes from the marine fish …

The tumor necrosis factor α of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a …

J García-Castillo, E Chaves-Pozo, P Olivares… - Cellular and Molecular …, 2004 - Springer
Abstract Information on the bioactivities of non-mammalian cytokines is scant due to the lack
of the recombinant molecules and specific antibodies. We produced the mature predicted …

Interleukin-1β isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines

P Pelegrı́n, J Garcı́a-Castillo, V Mulero, J Meseguer - Cytokine, 2001 - Elsevier
The gilthead seabream IL-1β gene consists of five exons/four introns. The complete coding
sequence contains a 102bp 5′ untranslated region (UTR), a single open reading frame of …

[HTML][HTML] A non-canonical function of telomerase RNA in the regulation of developmental myelopoiesis in zebrafish

F Alcaraz-Pérez, J García-Castillo… - Nature …, 2014 - nature.com
Dyskeratosis congenita (DC) is an inherited disorder with mutations affecting telomerase or
telomeric proteins. DC patients usually die of bone marrow failure. Here we show that …

[HTML][HTML] Como los labios de una misma boca: Cuatro acercamientos a la poesía mexicana de temas homosexual y gay

JE García Castillo - La ventana. Revista de estudios de género, 2013 - scielo.org.mx
Este trabajo propone que la poesía mexicana de temas gay y homosexual puede dividirse
cronológicamente en cuatro etapas sucesivas: una descriptiva, cuya dominante es referencial…

Telomerase RNA recruits RNA polymerase II to target gene promoters to enhance myelopoiesis

J García-Castillo, F Alcaraz-Pérez… - Proceedings of the …, 2021 - National Acad Sciences
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure and cancer predisposition
syndrome caused by mutations in telomerase or telomeric proteins. Here, we report that …