User profiles for Jesús Reiné
Dr. Jesús ReinéPostdoctoral Research Associate Verified email at paediatrics.ox.ac.uk Cited by 6237 |
[HTML][HTML] Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination
Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus
infection in animal models. In humans, the capacity of peripheral vaccination to generate …
infection in animal models. In humans, the capacity of peripheral vaccination to generate …
[HTML][HTML] Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2
Background Although recent epidemiological data suggest that pneumococci may contribute
to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in …
to the risk of SARS-CoV-2 disease, cases of coinfection with Streptococcus pneumoniae in …
[HTML][HTML] Inflammation induced by influenza virus impairs human innate immune control of pneumococcus
…, E Smith, JF Gritzfeld, C Solórzano, J Reine… - Nature …, 2018 - nature.com
Colonization of the upper respiratory tract by pneumococcus is important both as a determinant
of disease and for transmission into the population. The immunological mechanisms that …
of disease and for transmission into the population. The immunological mechanisms that …
[HTML][HTML] Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization
…, S Pojar, EL German, J Reiné… - The Journal of …, 2022 - Am Soc Clin Investig
Streptococcus pneumoniae (Spn) is a common cause of respiratory infection, but also frequently
colonizes the nasopharynx in the absence of disease. We used mass cytometry to study …
colonizes the nasopharynx in the absence of disease. We used mass cytometry to study …
[HTML][HTML] Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface
…, C Venturini, S Pojar, SP Jochems, J Reiné… - Nature …, 2019 - nature.com
Control of Streptococcus pneumoniae colonisation at human mucosal surfaces is critical to
reducing the burden of pneumonia and invasive pneumococcal disease, interrupting …
reducing the burden of pneumonia and invasive pneumococcal disease, interrupting …
Nasal pneumococcal density is associated with microaspiration and heightened human alveolar macrophage responsiveness to bacterial pathogens
Rationale: Pneumococcal pneumonia remains a global health problem. Colonization of the
nasopharynx with Streptococcus pneumoniae (Spn), although a prerequisite of infection, is …
nasopharynx with Streptococcus pneumoniae (Spn), although a prerequisite of infection, is …
[HTML][HTML] A leaky mutation in CD3D differentially affects αβ and γδ T cells and leads to a Tαβ–Tγδ+B+NK+ human SCID
…, A Díaz-Alderete, J Navarro, J Reiné… - The Journal of …, 2011 - Am Soc Clin Investig
T cells recognize antigens via their cell surface TCR and are classified as either αβ or γδ
depending on the variable chains in their TCR, α and β or γ and δ, respectively. Both αβ and γδ …
depending on the variable chains in their TCR, α and β or γ and δ, respectively. Both αβ and γδ …
[HTML][HTML] Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage
The ability of pneumococcal conjugate vaccine (PCV) to decrease transmission by blocking
the acquisition of colonization has been attributed to herd immunity. We describe the role of …
the acquisition of colonization has been attributed to herd immunity. We describe the role of …
[HTML][HTML] Single use and conventional bronchoscopes for Broncho alveolar lavage (BAL) in research: a comparative study (NCT 02515591)
Background Broncho alveolar lavage (BAL) is widely used for investigative research to
study innate, cellular and humoral immune responses, and in early phase drug trials. …
study innate, cellular and humoral immune responses, and in early phase drug trials. …
Experimental human pneumococcal colonization in older adults is feasible and safe, not immunogenic
Rationale: Pneumococcal colonization is key to the pathogenesis of invasive disease but is
also immunogenic in young adults, protecting against recolonization. Colonization is rarely …
also immunogenic in young adults, protecting against recolonization. Colonization is rarely …