[PDF][PDF] Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms

…, BS Phinney, M Salemi, JR Alexander… - Cell Reports …, 2021 - cell.com
Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological
symptoms, but the biological underpinnings of these phenomena are unknown. Through single-…

[HTML][HTML] Multiple sclerosis therapies differentially affect SARS-CoV-2 vaccine–induced antibody and T cell immunity and function

…, CM Spencer, SA Sagan, DG Augusto, JR Alexander… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Vaccine-elicited adaptive immunity is a prerequisite for control of SARS-CoV-2
infection. Multiple sclerosis (MS) disease-modifying therapies (DMTs) differentially target …

Anti–SARS-CoV-2 and autoantibody profiles in the cerebrospinal fluid of 3 teenaged patients with COVID-19 and subacute neuropsychiatric symptoms

…, CR Zamecnik, KC Zorn, JR Alexander… - JAMA …, 2021 - jamanetwork.com
Importance Neuropsychiatric manifestations of COVID-19 have been reported in the
pediatric population. Objective To determine whether anti–SARS-CoV-2 and autoreactive …

[HTML][HTML] Longitudinal adaptive immune responses following sequential SARS-CoV-2 vaccinations in MS patients on anti-CD20 therapies and sphingosine-1 …

…, CM Spencer, SA Sagan, J Alexander… - Multiple Sclerosis and …, 2023 - Elsevier
Background Adequate response to the SARS-CoV-2 vaccine represents an important
treatment goal in caring for patients with multiple sclerosis (MS) during the ongoing COVID-19 …

[HTML][HTML] Impact of multiple sclerosis disease-modifying therapies on SARS-CoV-2 vaccine-induced antibody and T cell immunity

…, CM Spencer, SA Sagan, DG Augusto, J Alexander… - medRxiv, 2021 - ncbi.nlm.nih.gov
Vaccine-elicited adaptive immunity is an essential prerequisite for effective prevention and
control of coronavirus 19 (COVID-19). Treatment of multiple sclerosis (MS) involves a diverse …

[HTML][HTML] Exploratory neuroimmune profiling identifies CNS-specific alterations in COVID-19 patients with neurological involvement

…, BS Phinney, M Salemi, J Alexander… - bioRxiv, 2020 - ncbi.nlm.nih.gov
One third of COVID-19 patients develop significant neurological symptoms, yet SARS-CoV-2
is rarely detected in central nervous system (CNS) tissue, suggesting a potential role for …

Characteristics of multiple sclerosis and demyelinating disease in an Asian American population

JH Fan, J Alexander, S Poole… - Multiple Sclerosis …, 2023 - journals.sagepub.com
Background: Race and ancestry influence the course of multiple sclerosis (MS). Objectives:
Explore clinical characteristics of MS and neuromyelitis optica spectrum disorder (NMOSD) …

Do PEEK rods for posterior instrumented fusion in the lumbar spine reduce the risk of adjacent segment disease?

…, JE Harris, EW Paxton, J Alexander… - International Journal of …, 2021 - ijssurgery.com
Background: Polyetheretherketone (PEEK) rods were clinically introduced in the mid-2000s
as an alternative to titanium (Ti) rods for posterior instrumented lumbar spine fusion, …

[HTML][HTML] Case report: a false negative case of anti-yo paraneoplastic myelopathy

…, NN Parikshak, TT Ngo, JA Alexander… - Frontiers in …, 2021 - frontiersin.org
The development of autoimmune antibody panels has improved the diagnosis of paraneoplastic
neurological disorders (PNDs) of the brain and spinal cord. Here, we present a case of …

[PDF][PDF] Longitudinal analysis of adaptive immunity following additional SARS-CoV-2 vaccination in MS patients on anti-CD20 therapies and sphingosine-1-phosphate …

…, SA Sagan, J Alexander… - … for Treatment and …, 2022 - medcommshydhosting.com
1 Sabatino, et al. Multiple sclerosis therapies differentially impact SARS-CoV-2 vaccine-
induced antibody and T cell immunity and function. JCI Insight. 2022