Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption

…, Y Li, W Liu, AN Avitto, JC DeVoto, J Connell… - Science translational …, 2021 - science.org
Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission.
However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an …

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

…, RM Russell, F Bibollet-Ruche, W Liu, J Connell… - Science, 2021 - science.org
INTRODUCTION It is widely believed that the development of an effective neutralizing
antibody–based HIV-1 vaccine will require consistent activation of multiple germline precursor B …

[HTML][HTML] Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes

…, W Liu, Y Li, DE Loy, E Mollison, J Connell… - Nature …, 2022 - nature.com
The human parasite Plasmodium malariae has relatives infecting African apes (Plasmodium
rodhaini) and New World monkeys (Plasmodium brasilianum), but its origins remain …

CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses

…, W Liu, S Sherrill-Mix, Y Li, J Connell… - Proceedings of the …, 2021 - National Acad Sciences
Infection with human and simian immunodeficiency viruses (HIV/SIV) requires binding of the
viral envelope glycoprotein (Env) to the host protein CD4 on the surface of immune cells. …

[HTML][HTML] T cell dynamics and response of the microbiota after gene therapy to treat X-linked severe combined immunodeficiency

EL Clarke, AJ Connell, E Six, NA Kadry, AA Abbas… - Genome medicine, 2018 - Springer
Background Mutation of the IL2RG gene results in a form of severe combined immune
deficiency (SCID-X1), which has been treated successfully with hematopoietic stem cell gene …

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

…, Y Park, R Baum, JW Carey, AJ Connell… - Mbio, 2023 - Am Soc Microbiol
HIV-1 and its SIV precursors share a broadly neutralizing antibody (bNAb) epitope in
variable loop 2 (V2) at the envelope glycoprotein (Env) trimer apex. Here, we tested the …

CHIIMP: An automated high‐throughput microsatellite genotyping platform reveals greater allelic diversity in wild chimpanzees

HJ Barbian, AJ Connell, AN Avitto… - Ecology and …, 2018 - Wiley Online Library
Short tandem repeats ( STR s), also known as microsatellites, are commonly used to
noninvasively genotype wild‐living endangered species, including African apes. Until recently, …

[HTML][HTML] Malaria-driven adaptation of MHC class I in wild bonobo populations

…, W Liu, Y Li, SE Heisel, AJ Connell… - Nature …, 2023 - nature.com
The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in
equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell …

Barriers to chimpanzee gene flow at the south‐east edge of their distribution

…, AK Piel, RP Brown, Y Li, AJ Connell… - Molecular …, 2023 - Wiley Online Library
Populations on the edge of a species' distribution may represent an important source of
adaptive diversity, yet these populations tend to be more fragmented and are more likely to be …

[HTML][HTML] Heightened resistance to type 1 interferons characterizes HIV-1 at transmission and following treatment interruption

…, W Liu, AN Avitto, JC DeVoto, J Connell… - Science translational …, 2021 - ncbi.nlm.nih.gov
Type 1 interferons (IFN-I) are potent innate antiviral effectors that constrain HIV-1 transmission.
However, harnessing these cytokines for HIV-1 cure strategies has been hampered by an …