Macrophages perform diverse functions within tissues during immune responses to pathogens
and injury, but molecular mechanisms by which physical properties of the tissue regulate …

Piezo channels transduce mechanical stimuli into electrical and chemical signals to powerfully
influence development, tissue homeostasis, and regeneration. Studies on Piezo1 have …

Keratinocytes, the predominant cell type of the epidermis, migrate to reinstate the epithelial
barrier during wound healing. Mechanical cues are known to regulate keratinocyte re-…

T lymphocytes encounter complex mechanical cues during an immune response. The
mechanosensitive ion channel, Piezo1, drives inflammatory responses to bacterial infections, …

Keratinocytes are the predominant cell type of the epidermis and form an important protective
barrier to the external environment. During the healing of wounded skin, keratinocytes …

The human mechanosensitive ion channel PIEZO1 is gated by membrane tension and
regulates essential biological processes such as vascular development and erythrocyte volume …

The collective migration of keratinocytes during wound healing requires both the generation
and transmission of mechanical forces for individual cellular locomotion and the …

Holt JR, Zeng WZ, Evans EL, Woo SH, Ma S, Abuwarda H, Loud M, Patapoutian A, Pathak
MM. 2021. Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration …

PIEZO1 channels play a critical role in numerous physiological processes by transducing
diverse mechanical stimuli into electrical and chemical signals. Recent studies underscore the …

Piezo channels transduce mechanical stimuli into electrical and chemical signals to
powerfully influence development, homeostasis, and regeneration. Due to their location in the …