The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Development is tightly connected to aging, but whether pharmacologically targeting
development can extend life remains unknown. Here, we subjected genetically diverse UMHET3 …

The search for biomarkers that quantify biological aging (particularly ‘omic’-based biomarkers)
has intensified in recent years. Such biomarkers could predict aging-related outcomes …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging are …

Proximity enhancement is a central chemical tenet underpinning an exciting suite of small-molecule
toolsets that have allowed us to unravel many biological complexities. The leitmotif …

Despite the emerging importance of reactive electrophilic drugs, deconvolution of their
principal targets remains difficult. The lack of genetic tractability/interventions and reliance on …

The field of aging is at a precipice. Attention and funding are increasingly focused on this
area, and exciting, fundamentally important findings are being reported literally every day. As …

The nuclear factor erythroid 2–related factor 2 (Nrf2) signaling axis is a target of covalent
drugs and bioactive native electrophiles. However, much of our understanding of Nrf2 …

Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed
phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using …