Advances in the study of neurological conditions have been possible because of pluripotent
stem cell technologies and organoids. Studies have described the generation of neural …

Neuronal communication relies on the release of neurotransmitters from various populations
of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities, …

Depolarization of presynaptic terminals stimulates calcium influx, which evokes neurotransmitter
release and activates phosphorylation-based signalling. Here, we present the first …

Stable function of networks requires that synapses adapt their strength to levels of neuronal
activity, and failure to do so results in cognitive disorders. How such homeostatic regulation …

Dysferlin is a Ca 2+ -activated lipid binding protein implicated in muscle membrane repair.
Recessive variants in DYSF result in dysferlinopathy, a progressive muscular dystrophy. We …

Advances in the study of neurological conditions have been possible due to induced pluripotent
stem cell technologies and the generation of neural cell types and organoids. Numerous …

Phosphorylation is an essential regulatory protein modification, which modulates many
presynaptic processes, including synaptic vesicle trafficking. Protein phosphorylation impacts …

Advances in the study of neurological conditions have been possible because of pluripotent
stem cell technologies and organoids. Studies have described the generation of neural …

The clathrin heavy chain N-terminal domain interacts with endocytic adapter proteins via
clathrin binding motifs to assemble clathrin triskelia into cages. However, the precise …

Clathrin-mediated endocytosis at the nerve terminal is dependent on assembly protein 180 (AP180)
and adapter protein complex 2 (AP2). Both membrane adapter proteins bind to each …