MicroRNA-mediated inhibition of transgene expression reduces dorsal root ganglion toxicity by AAV vectors in primates
…, Y Yuan, Y Zhu, P Bell, M Li, JA Chichester… - Science translational …, 2020 - science.org
Delivering adeno-associated virus (AAV) vectors into the central nervous system of nonhuman
primates (NHPs) via the blood or cerebral spinal fluid is associated with dorsal root …
primates (NHPs) via the blood or cerebral spinal fluid is associated with dorsal root …
[HTML][HTML] A Plant-Produced Pfs25 VLP Malaria Vaccine Candidate Induces Persistent Transmission Blocking Antibodies against Plasmodium falciparum in Immunized …
RM Jones, JA Chichester, V Mett, J Jaje, S Tottey… - PloS one, 2013 - journals.plos.org
Malaria transmission blocking vaccines (TBVs) are considered an effective means to control
and eventually eliminate malaria. The Pfs25 protein, expressed predominantly on the …
and eventually eliminate malaria. The Pfs25 protein, expressed predominantly on the …
[HTML][HTML] Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study …
JA Chichester, BJ Green, RM Jones, Y Shoji, K Miura… - Vaccine, 2018 - Elsevier
Malaria continues to be one of the world’s most devastating infectious tropical diseases, and
alternative strategies to prevent infection and disease spread are urgently needed. These …
alternative strategies to prevent infection and disease spread are urgently needed. These …
[HTML][HTML] Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration
…, Y Zhu, Z He, J White, JX Zhu, JA Chichester… - Nature …, 2023 - nature.com
The development of liver-based adeno-associated virus (AAV) gene therapies is facing
concerns about limited efficiency and durability of transgene expression. We evaluated …
concerns about limited efficiency and durability of transgene expression. We evaluated …
Plant-derived hemagglutinin protects ferrets against challenge infection with the A/Indonesia/05/05 strain of avian influenza
…, N Ugulava, S Rabindran, V Mett, JA Chichester… - Vaccine, 2009 - Elsevier
The global spread of highly pathogenic avian influenza virus (H5N1 subtype) has promoted
efforts to develop human vaccines against potential pandemic outbreaks. However, current …
efforts to develop human vaccines against potential pandemic outbreaks. However, current …
A plant‐based system for rapid production of influenza vaccine antigens
…, M Shamloul, S Sharma, JA Chichester… - Influenza and other …, 2012 - Wiley Online Library
Please cite this paper as: Shoji et al. (2011) A plant‐based system for rapid production of
influenza vaccine antigens. Influenza and Other Respiratory Viruses 6(3), 204–210. …
influenza vaccine antigens. Influenza and Other Respiratory Viruses 6(3), 204–210. …
Plant-based rapid production of recombinant subunit hemagglutinin vaccines targeting H1N1 and H5N1 influenza
Y Shoji, JA Chichester, M Jones, SD Manceva… - Human …, 2011 - Taylor & Francis
In 2009, a novel H1N1 swine influenza virus was isolated from infected humans in Mexico
and the United States, and rapidly spread around the world. Another virus, a highly …
and the United States, and rapidly spread around the world. Another virus, a highly …
Plant-expressed HA as a seasonal influenza vaccine candidate
Y Shoji, JA Chichester, H Bi, K Musiychuk… - Vaccine, 2008 - Elsevier
Influenza is a globally important respiratory pathogen that causes a high degree of morbidity
and mortality annually. Although current vaccines are effective against virus infection, new …
and mortality annually. Although current vaccines are effective against virus infection, new …
A plant-produced Pfs230 vaccine candidate blocks transmission of Plasmodium falciparum
…, S Sharma, V Mett, JA Chichester… - Clinical and Vaccine …, 2011 - Am Soc Microbiol
Plasmodium falciparum is transmitted to a new host after completing its sexual cycle within a
mosquito. Developing vaccines against the parasite sexual stages is a critical component in …
mosquito. Developing vaccines against the parasite sexual stages is a critical component in …
Safe and sustained expression of human iduronidase after intrathecal administration of adeno-associated virus serotype 9 in infant rhesus monkeys
…, JP Louboutin, T Jahan, P Bell, JA Chichester… - Human Gene …, 2019 - liebertpub.com
… Jessica A. Chichester … Chichester, Alice F. Tarantal, and James M. Wilson.…