Endothelial migration is a crucial aspect of a variety of physiologic and pathologic conditions
including atherosclerosis and vascular repair. Reactive oxygen species (ROS) function as …

Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for
Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites …

Tumors display increased uptake and processing of nutrients to fulfill the demands of rapidly
proliferating cancer cells. Seminal studies have shown that the proto-oncogene MYC …

Agents, such as β-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase
1 (NQO1), to induce programmed necrosis in solid tumors have shown great promise, but …

Therapeutic drugs that block DNA repair, including poly(ADP-ribose) polymerase (PARP)
inhibitors, fail due to lack of tumor-selectivity. When PARP inhibitors and β-lapachone are …

Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis
model, we examined the role of mitochondrial reactive oxygen species in sepsis-mediated …

Lung cancer is one of the most lethal forms of cancer and current chemotherapeutic strategies
lack broad specificity and efficacy. Recently, β-lapachone (β-lap) was shown to be highly …

Glioblastoma is the most common and aggressive type of cancer in the brain; its poor
prognosis is often marked by reoccurrence due to resistance to the chemotherapeutic agent …

Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification
catalyzed by the PARP1/2: HPF1 complex. As the list of PARP1/2: HPF1 substrates continues …

Purpose: Development of tumor-specific therapies for the treatment of recalcitrant non–small
cell lung cancers (NSCLC) is urgently needed. Here, we investigated the ability of β-…