Structure of the hexagonal surface layer on Caulobacter crescentus cells

…, GG Hardy, EW Yu, JM Devant… - Nature …, 2017 - nature.com
Many prokaryotic cells are encapsulated by a surface layer (S-layer) consisting of repeating
units of S-layer proteins. S-layer proteins are a diverse class of molecules found in Gram-…

[HTML][HTML] Structural heterogeneity of a human norovirus vaccine candidate

JM Devant, GS Hansman - Virology, 2021 - Elsevier
Human norovirus virus-like particles (VLPs) are assumed to be morphologically and
antigenically similar to virion particles. The norovirus virion is assembled from 180 copies of the …

Heterologous expression of human norovirus GII. 4 VP1 leads to assembly of T= 4 virus-like particles

JM Devant, G Hofhaus, D Bhella, GS Hansman - Antiviral research, 2019 - Elsevier
Human noroviruses are a leading cause of acute gastroenteritis, yet there are still no vaccines
or antivirals available. Expression of the norovirus capsid protein (VP1) in insect cells …

Structural basis of nanobodies targeting the prototype norovirus

K Ruoff, T Kilic, J Devant, A Koromyslova… - Journal of …, 2019 - Am Soc Microbiol
Human norovirus infections are a major disease burden. In this study, we analyzed three
new norovirus-specific Nanobodies that interacted with the prototype human norovirus (ie, …

Nanobody-mediated neutralization reveals an achilles heel for norovirus

AD Koromyslova, JM Devant, T Kilic, CD Sabin… - Journal of …, 2020 - Am Soc Microbiol
Human norovirus frequently causes outbreaks of acute gastroenteritis. Although discovered
more than five decades ago, antiviral development has, until recently, been hampered by …

[HTML][HTML] Natural extracts, honey, and propolis as human norovirus inhibitors

K Ruoff, JM Devant, G Hansman - Scientific Reports, 2022 - nature.com
Norovirus is the most important cause of acute gastroenteritis, yet there are still no antivirals,
vaccines, or treatments available. Several studies have shown that norovirus-specific …

Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies

G Kher, C Sabin, JH Lun, JM Devant, K Ruoff… - Journal of …, 2023 - Am Soc Microbiol
Noroviruses are the leading cause of outbreaks of acute gastroenteritis. These viruses
usually interact with histo-blood group antigens (HBGAs), which are considered essential …

Structural Basis for Rabbit Hemorrhagic Disease Virus Antibody Specificity

MM Leuthold, T Kilic, JM Devant, O Landeta… - Journal of …, 2022 - Am Soc Microbiol
Rabbit hemorrhagic disease virus (RHDV) typically causes a fatal disease in rabbits. In Australia,
RHDV was imported to control the feral rabbit population, while it poses a severe threat …

Novel structural features of human norovirus capsid

J Devant, G Hofhaus, GS Hansman - bioRxiv, 2019 - biorxiv.org
Human noroviruses are a major cause of gastroenteritis, yet there are still no vaccines or
antivirals available. Nevertheless, a number of vaccine candidates that are currently in clinical …

Deciphering structural variations within the norovirus capsid

JM Devant - 2020 - ub.uni-heidelberg.de
Norovirus is one of the most common agents associated with acute gastroenteritis. Despite
its discovery 50 years ago, as of now there is no cure or treatment, and knowledge about the …