Glycosylation defects are a hallmark of many nervous system diseases. However, the molecular
and metabolic basis for this pathology is not fully understood. In this study, we found that …

The addition of phosphate groups into glycogen modulates its branching pattern and
solubility which all impact its accessibility to glycogen interacting enzymes. As glycogen …

Conventional two-dimensional (2D) cell cultures are grown on rigid plastic substrates with
unrealistic concentration gradients of O 2 , nutrients, and treatment agents. More importantly, …

… La and ka indicate the lactone (C1-oxidation) and ketoaldose (C4-oxidation) form of the
oxidized cello-oligosaccharide, respectively. In addition, OI corresponds to oxygen incorporation …

The increasing prevalence of age-related diseases and resulting healthcare insecurity and
emotional burden require novel treatment approaches. Several promising strategies seek to …

Large clinical trials and model systems studies suggest that the chemical form of selenium
dictates chemopreventive and chemotherapeutic efficacy. Selenite induces excess ROS …

In the present study we conducted proteomic and pharmacological characterizations of the
venom extracted from the Brazilian tarantula Acanthoscurria paulensis, and evaluated the …

Skin blistering as a result of snakebite envenomation is characteristic of some bites, however
little is known regarding the mechanism of blister formation or the composition of the blister …

Lafora disease (LD) is a fatal childhood dementia with severe epilepsy and also a glycogen
storage disease that is caused by recessive mutations in either the EPM2A or EPM2B genes…

Parkinson’s disease (PD) and essential tremor (ET) are two common adult-onset tremor
disorders in which prevalence increases with age. PD is a neurodegenerative condition with …