Humans differ in their susceptibility to infectious disease, partly owing to variation in the
immune response after infection. We used single-cell RNA sequencing to quantify variation in …

Renal sympathetic denervation (RDNx) has emerged as a novel therapy for hypertension;
however, the therapeutic mechanisms remain unclear. Efferent renal sympathetic nerve …

Laboratory mice comprise an expeditious model for preclinical vaccine testing; however,
vaccine immunogenicity in these models often inadequately translates to humans. …

The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow
cytometry and single cell RNA-sequencing to understand how the heterogeneity of this diverse …

Influenza A viruses (IAV) can cause severe disease and death in humans. IAV infection and
the accompanying immune response can result in systemic inflammation, leading to …

Influenza A virus drives significant morbidity and mortality in humans and livestock. Annual
circulation of the virus in livestock and waterfowl contributes to severe economic disruption …

Resident memory T cells (T RM) in the lung are vital for heterologous protection against
influenza A virus (IAV). Environmental factors are necessary to establish lung T RM; however, …

Influenza virus has a broad cellular tropism in the respiratory tract. Infected epithelial cells
sense the infection and initiate an antiviral response. To define the antiviral response at the …

Background The transfer of passive immunity with convalescent plasma is a promising
strategy for treatment and prevention of COVID‐19, but donors with a history of nonsevere …

Influenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce
the eventual death of all infected cells. We and others have shown however, that infection …