Cardiac contractility is regulated by changes in intracellular Ca concentration ([Ca 2+ ] i ).
Normal function requires that [Ca 2+ ] i be sufficiently high in systole and low in diastole. Much …

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

Rationale: Transverse tubules (t-tubules) regulate cardiac excitation–contraction coupling
and exhibit interchamber and interspecies differences in expression. In cardiac disease, t-…

Normal cardiac function requires that intracellular Ca 2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Novel cardioprotective agents are needed in both heart failure (HF) and myocardial infarction.
Increasing evidence from cellular studies and animal models indicate protective effects of …

The intercalated disc (ICD) orchestrates electrochemical and mechanical communication
between neighboring cardiac myocytes, properties that are perturbed in heart failure (HF). …

Non‐technical summary Heart failure is where the heart is unable to pump sufficient blood
in order to meet the requirements of the body. Symptoms of heart failure often first present …

Heart failure (HF) is commonly associated with reduced cardiac output and an increased
risk of atrial arrhythmias particularly during β-adrenergic stimulation. The aim of the present …

Heart failure (HF) is characterized by poor survival, a loss of catecholamine reserve and
cellular structural remodeling in the form of disorganization and loss of the transverse tubule …

Key points Ageing is associated with an increased risk of cardiovascular disease and
arrhythmias, with the most common arrhythmia being found in the atria of the heart. Little is known …