Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but
mechanisms controlling the duration of cellular caspase-1 activity are unknown. Caspase-1 is …

Cell migration and spreading is driven by actin polymerization and actin stress fibers. Actin
stress fibers are considered to contain α-actinin crosslinkers and nonmuscle myosin II motors. …

Epithelia are active materials where mechanical tension governs morphogenesis and
homeostasis. But how that tension is regulated remains incompletely understood. We now report …

Epithelia can eliminate apoptotic cells by apical extrusion. This is a complex morphogenetic
event where expulsion of the apoptotic cell is accompanied by rearrangement of its …

Cellular traction forces influence epithelial behavior, including wound healing and cell extrusion.
Here, we describe a simple in vitro traction force microscopy (TFM) protocol using ECM …

Cell extrusion is a striking morphological event found in epithelia and endothelia. It is
distinguished by two symmetry-breaking events: a loss of planar symmetry, as cells are extruded in …

Rho kinases (ROCK1 and ROCK2) function downstream of the small GTPase RhoA to drive
actomyosin cytoskeletal remodeling. It has often been believed that ROCK1 and ROCK2 …

Epithelial networks are commonly generated by processes where multicellular aggregates
elongate and branch. Here, we focus on understanding cellular mechanisms for elongation …

Background Information Epithelial collective cell migration requires the intrinsic locomotor
activity of cells to be coordinated across populations. This coordination is governed by the …

Classical cadherin cell adhesion receptors are integral membrane proteins that mediate cell–cell
interactions, tissue integrity and morphogenesis. Cadherins are best understood to …