10.7554/eLife.36401.001 Cognitive and social capacities require postnatal experience, yet
the pathways by which experience guides development are unknown. Here we show that the …

Clinical studies indicate alternate-day, intermittent fasting (IMF) protocols result in meaningful
weight loss in obese individuals. To further understand the mechanisms sustaining weight …

Cerebellar outputs take polysynaptic routes to reach the rest of the brain, impeding conventional
tracing. Here, we quantify pathways between the cerebellum and forebrain by using …

The cerebellum, traditionally associated with motor coordination and balance, also plays a
crucial role in various aspects of higher-order function and dysfunction. Emerging research …

The cerebellum regulates nonmotor behavior, but the routes of influence are not well
characterized. Here we report a necessary role for the posterior cerebellum in guiding a reversal …

Background Repetitive action, resistance to environmental change and fine motor disruptions
are hallmarks of autism spectrum disorder (ASD) and other neurodevelopmental disorders…

Prolonged consumption of ketogenic diets (KD) has reported neuroprotective benefits. Several
studies suggest KD interventions could be useful in the management of neurological and …

Introduction: Obesity is a known health risk for the development of several preventable
diseases. Obesity-related metabolic alterations negatively impact different physiological …

Adeno-associated viral (AAV) vectors are an established and safe gene delivery tool to target
the nervous system. However, the payload capacity of <4.9 kb limits the transfer of large or …

Extracts from the immature fruit of Citrus aurantium are often used for weight loss but are
reported to produce adverse cardiovascular effects. Root extracts of Rhodiola rosea have …