Macrophages have a key role in shaping the tumour microenvironment (TME), tumour
immunity and response to immunotherapy, which makes them an important target for cancer …

Checkpoint blockade therapies have improved cancer treatment, but such immunotherapy
regimens fail in a large subset of patients. Conventional type 1 dendritic cells (DC1s) control …

Natural killer (NK) cells are commonly reduced in human tumors, enabling many to evade
surveillance. Here, we sought to identify cues that alter NK cell activity in tumors. We found that…

Although it has been more than 2 years since the start of the coronavirus disease 2019 (COVID-19)
pandemic, COVID-19 continues to be a worldwide health crisis. Despite the …

Though it has been 2 years since the start of the Coronavirus Disease 19 (COVID-19)
pandemic, COVID-19 continues to be a worldwide health crisis. Despite the development of …

Immunotherapy is becoming a mainstay in the treatment of NSCLC. While tumor mutational
burden (TMB) has been shown to correlate with response to immunotherapy, little is known …

… Chen, Navpreet Tung, Christie Chang and Jessica LeBerichel … Chen 1 2 3 , Navpreet
Tung 1 2 , Christie Chang 1 4 , Jessica LeBerichel 1 2 3 , Aleksey Chudnovskiy 1 2 3 15 …

Progressive neurodegeneration is a devastating and ultimately fatal complication in some
survivors of multi-system high-risk Langerhans Cell Histiocytosis (LCH). Patients often …

Though it has been 2 years since the start of the Coronavirus Disease 19 (COVID-19)
pandemic, COVID-19 continues to be a worldwide health crisis. Despite the development of …

… Soma Kobayashi, Christie Chang, Alexandra Tabachnikova, and Jessica LeBerichel, have
been fantastic lab mates providing large amounts of technical and logistical support and have …