Use of marijuana during pregnancy is fairly commonplace and can be expected increase in
frequency as more states legalize its recreational use. The cannabinoids present in …

Expression of the transcription factor Helios by Tregs ensures stable expression of a suppressive
and anergic phenotype in the face of intense inflammatory responses, whereas Helios-…

∆ 9 -Tetrahydrocannabinol (THC) is one of the major bioactive cannabinoids derived from
the Cannabis sativa plant and is known for its anti-inflammatory properties. Delayed-type …

Regulatory T cells (Treg) can impede antitumor immunity and currently represent a major
obstacle to effective cancer immunotherapy. Targeting tumor-infiltrating regulatory Treg while …

Follicular regulatory T (T FR ) cells are a specialized suppressive subset that controls the
germinal center (GC) response and maintains humoral self-tolerance. The mechanisms that …

Immune cells have been shown to express cannabinoid receptors and to produce endogenous
ligands. Moreover, activation of cannabinoid receptors on immune cells has been shown …

Endocannabinoids are endogenous ligands for the cannabinoid (CB) receptors which
include anandamide (AEA) and 2‐arachidonyl glycerol (2‐AG). 2‐AG has been linked to …

The impact of the endogenous cannabinoids (AEA, 2-AG, PEA, and virodamine) on the
immune cell expressed cannabinoid receptors (CB1, CB2, TRPV-1, and GPR55) and …

Non-viral approaches to transfection have emerged a viable option for gene transfer. Electro-mechanical
transfection involving use of electric fields coupled with high fluid flow rates is a …

MDSCs are potent immunosuppressive cells that are induced during inflammatory responses,
as well as by cancers, to evade the anti-tumor immunity. We recently demonstrated that …