Parent-of-origin effects are unexpectedly common in complex traits, including metabolic and
neurological traits. Parent-of-origin effects can be modified by the environment, but the …

Results: HPX expression in mouse adipose tissue, but not in liver, was regulated by dietary
fat regardless of genetic background. HPX increased in concert with adipogenesis in 3T3-L1 …

The extracellular subunit of the major histocompatibility complex MHCII β plays an important
role in the recognition of pathogens and the initiation of the adaptive immune response of …

Allele-specific expression (ASE) is a phenomenon in which one allele is preferentially
expressed over the other. Genetic and epigenetic factors cause ASE by altering the final …

We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed SM/J
mice initially develop poor glucose homeostasis relative to controls. Strikingly, their glycemic …

Maintenance of functional β‐cell mass is critical to preventing diabetes, but the physiological
mechanisms that cause β‐cell populations to thrive or fail in the context of obesity are …

Metabolic syndrome (MetS) is a clustering of metabolic complications representing a
premorbid condition that is a substantial public health burden. Animal models provide an …

Background Iron is a critical component of metabolic homeostasis, but consumption of
dietary iron has increased dramatically in the last 30 years, corresponding with the rise of …

Disruption of glucose homeostasis increases the risk of type II diabetes, cardiovascular
disease, stroke, and cancer. We leverage a novel rodent model, the SM/J mouse, to understand …

Parent-of-origin effects (POE) are unexpectedly common in complex traits, including
metabolic and neurological diseases. POE can also be modified by the environment, but the …