Allosteric transcription factors (aTFs) have proven widely applicable for biotechnology and
synthetic biology as ligand-specific biosensors enabling real-time monitoring, selection and …

Metabolic engineering efforts toward rewiring metabolism of cells to produce new
compounds often require the utilization of non-native enzymatic machinery that is capable of …

Streptomyces have a rich history as producers of important natural products and this genus
of bacteria has recently garnered attention for its potential applications in the broader context …

Lactams are an important class of commodity chemicals used in the manufacture of nylons,
with millions of tons produced every year. Biological production of lactams could be greatly …

ε-Caprolactam and δ-valerolactam are important commodity chemicals used in the manufacture
of nylons, with millions of tons produced annually. Biological production of these highly …

Aluminum (Al) toxicity is a global issue that severely limits root growth in acidic soils. Isolation
of suppressors of the Arabidopsis thaliana Al-hypersensitive mutant, als3-1, resulted in …

Despite intensive study for 50 years, the biochemical and genetic links between lysine
metabolism and central metabolism in Pseudomonas putida remain unresolved. To establish …

Fatty acid synthases are dynamic ensembles of enzymes that can biosynthesize long
hydrocarbon chains efficiently. Here we visualize the interaction between the Escherichia coli acyl …

The terminal reductase (R) domain from the non-ribosomal peptide synthetase (NRPS)
module MxaA in Stigmatella aurantiaca Sga15 catalyzes a non-processive four-electron …

Caprolactam is an important polymer precursor to nylon traditionally derived from petroleum
and produced on a scale of 5 million tons per year. Current biological pathways for the …