User profiles for Jezreel Pantaleón García

Jezreel Pantaleón García

The University of Texas MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 200

A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo

…, VV Kulkarni, J Pantaleón García… - Proceedings of the …, 2020 - National Acad Sciences
There is a strong need for a new broad-spectrum antiinfluenza therapeutic, as vaccination
and existing treatments are only moderately effective. We previously engineered a lectin, …

[HTML][HTML] COVID-19 patients share common, corticosteroid-independent features of impaired host immunity to pathogenic molds

…, L Strobel, J Pantaleón García… - Frontiers in …, 2022 - frontiersin.org
Patients suffering from coronavirus disease-2019 (COVID-19) are susceptible to deadly
secondary fungal infections such as COVID-19-associated pulmonary aspergillosis and COVID-…

Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against viral infections

…, MM Leiva Juarez, P Shivshankar, J Pantaleón García… - MBio, 2018 - Am Soc Microbiol
Viral pneumonias cause profound worldwide morbidity, necessitating novel strategies to
prevent and treat these potentially lethal infections. Stimulation of intrinsic lung defenses via …

[HTML][HTML] Inducible lung epithelial resistance requires multisource reactive oxygen species generation to protect against bacterial infections

HH Ware, VV Kulkarni, Y Wang, J Pantaleón García… - PLoS …, 2019 - journals.plos.org
Pneumonia remains a global health threat, in part due to expanding categories of susceptible
individuals and increasing prevalence of antibiotic resistant pathogens. However, …

[PDF][PDF] OBIF: an omics-based interaction framework to reveal molecular drivers of synergy

J Pantaleón García, VV Kulkarni… - NAR Genomics and …, 2022 - academic.oup.com
Bioactive molecule library screening may empirically identify effective combination therapies,
but molecular mechanisms underlying favorable drug–drug interactions often remain …

Correlation and level of agreement between the ocular surface disease index and the symptom assessment in dry eye questionnaires: a survey-based study

…, A Bustamante-Arias, J Pantaleon-Garcia… - Current Eye …, 2023 - Taylor & Francis
Purpose The Ocular Surface Disease Index (OSDI) is the most frequently used dry eye disease
(DED) questionnaire, and the Symptom Assessment iN Dry Eye (SANDE) is the simplest …

[HTML][HTML] Antimicrobial mitochondrial reactive oxygen species induction by lung epithelial immunometabolic modulation

Y Wang, VV Kulkarni, J Pantaleón García… - PLoS …, 2023 - journals.plos.org
Pneumonia is a worldwide threat, making discovery of novel means to combat lower
respiratory tract infection an urgent need. Manipulating the lungs’ intrinsic host defenses by …

[HTML][HTML] Minimizing caging effects in murine lung microbiome studies

J Pantaleón García, RP Dickson… - American Journal of …, 2022 - journals.physiology.org
TO THE EDITOR: We read with interest the work by Abdelgawad et al.(1) regarding the role
of Toll-like receptors (TLRs) in shaping the pulmonary microbiome. We offer a clarification …

Immune modulation to improve survival of viral pneumonia in mice

…, DL Goldblatt, J Pantaleón García… - American journal of …, 2020 - atsjournals.org
Viral pneumonias remain global health threats, as exemplified in the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic, requiring novel treatment strategies …

Development of a corticosteroid-immunosuppressed mouse model to study the pathogenesis and therapy of influenza-associated pulmonary aspergillosis

S Wurster, J Pantaleón García, ND Albert… - The Journal of …, 2023 - academic.oup.com
Influenza-associated pulmonary aspergillosis (IAPA) is a feared complication in patients
with influenza tracheobronchitis, especially those receiving corticosteroids. Herein, we …