Crystal structure of Argonaute and its implications for RISC slicer activity
JJ Song, SK Smith, GJ Hannon, L Joshua-Tor - science, 2004 - science.org
Argonaute proteins and small interfering RNAs (siRNAs) are the known signature
components of the RNA interference effector complex RNA-induced silencing complex (RISC). …
components of the RNA interference effector complex RNA-induced silencing complex (RISC). …
Structural basis of recognition and destabilization of the histone H2B ubiquitinated nucleosome by the DOT1L histone H3 Lys79 methyltransferase
DOT1L is a histone H3 Lys79 methyltransferase whose activity is stimulated by histone H2B
Lys120 ubiquitination, suggesting cross-talk between histone H3 methylation and H2B …
Lys120 ubiquitination, suggesting cross-talk between histone H3 methylation and H2B …
Argonaute2 is the catalytic engine of mammalian RNAi
…, FV Rivas, CG Marsden, JM Thomson, JJ Song… - Science, 2004 - science.org
Gene silencing through RNA interference (RNAi) is carried out by RISC, the RNA-induced
silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) …
silencing complex. RISC contains two signature components, small interfering RNAs (siRNAs) …
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome
To equalize X-chromosome dosages between the sexes, the female mammal inactivates one
of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of …
of her two X chromosomes. X-chromosome inactivation (XCI) is initiated by expression of …
[PDF][PDF] Genome-wide identification of polycomb-associated RNAs by RIP-seq
…, JT Kung, Y Ogawa, DJ Grau, K Sarma, JJ Song… - Molecular cell, 2010 - cell.com
Polycomb proteins play essential roles in stem cell renewal and human disease. Recent
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …
studies of HOX genes and X inactivation have provided evidence for RNA cofactors in …
Purified Argonaute2 and an siRNA form recombinant human RISC
FV Rivas, NH Tolia, JJ Song, JP Aragon, J Liu… - Nature structural & …, 2005 - nature.com
Genetic, biochemical and structural studies have implicated Argonaute proteins as the
catalytic core of the RNAi effector complex, RISC. Here we show that recombinant, human …
catalytic core of the RNAi effector complex, RISC. Here we show that recombinant, human …
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes
JJ Song, J Liu, NH Tolia, J Schneiderman… - Nature Structural & …, 2003 - nature.com
RISC, the RNA-induced silencing complex, uses short interfering RNAs (siRNAs) or micro
RNAs (miRNAs) to select its targets in a sequence-dependent manner. Key RISC components …
RNAs (miRNAs) to select its targets in a sequence-dependent manner. Key RISC components …
[HTML][HTML] Epigenetics: an emerging player in gastric cancer
Cancers, like other diseases, arise from gene mutations and/or altered gene expression,
which eventually cause dysregulation of numerous proteins and noncoding RNAs. Changes in …
which eventually cause dysregulation of numerous proteins and noncoding RNAs. Changes in …
[PDF][PDF] Human Argonaute 2 has diverse reaction pathways on target RNAs
Argonaute is a key enzyme of various RNA silencing pathways. We use single-molecule
fluorescence measurements to characterize the reaction mechanisms of the core-RISC (RNA-…
fluorescence measurements to characterize the reaction mechanisms of the core-RISC (RNA-…
Argonaute and RNA—getting into the groove
JJ Song, L Joshua-Tor - Current opinion in structural biology, 2006 - Elsevier
RNAi has made an enormous impact on biology in a very short period of time. It became an
extraordinarily useful and simple tool for gene silencing, even as its fascinating mechanism …
extraordinarily useful and simple tool for gene silencing, even as its fascinating mechanism …