[HTML][HTML] Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
Innate lymphoid cells (ILCs) and CD4 + T cells produce IL-22, which is critical for intestinal
immunity. The microbiota is central to IL-22 production in the intestines; however, the factors …
immunity. The microbiota is central to IL-22 production in the intestines; however, the factors …
A comprehensive review of polyacrylamide polymer gels for conformance control
B Bai, J Zhou, M Yin - Petroleum exploration and development, 2015 - Elsevier
Polymer gels have been designed and successfully applied to improve sweep efficiency and
to reduce excessive water production by minimizing reservoir heterogeneity. Based on their …
to reduce excessive water production by minimizing reservoir heterogeneity. Based on their …
A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors
DNA polymerase theta (POLθ or POLQ) is synthetic lethal with homologous recombination (HR)
deficiency and is thus a candidate target for HR-deficient cancers. Through high-…
deficiency and is thus a candidate target for HR-deficient cancers. Through high-…
Broad spectrum antiviral agent niclosamide and its therapeutic potential
The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for
therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an …
therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an …
Nd3+-Sensitized Upconversion Nanophosphors: Efficient In Vivo Bioimaging Probes with Minimized Heating Effect
Upconversion (UC) process in lanthanide-doped nanomaterials has attracted great research
interest for its extensive biological applications in vitro and in vivo, benefiting from the high …
interest for its extensive biological applications in vitro and in vivo, benefiting from the high …
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
J Peng, BF Sun, CY Chen, JY Zhou, YS Chen, H Chen… - Cell research, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …
Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K+ channel block
We have analyzed the role of glutamate and its receptors (GluRs) in regulating the
development of oligodendrocytes. Activation of AMPA- preferring GluRs with selective agonists …
development of oligodendrocytes. Activation of AMPA- preferring GluRs with selective agonists …
Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin
Chronic neuroinflammation is a common feature of the ageing brain and some neurodegenerative
disorders. However, the molecular and cellular mechanisms underlying the regulation …
disorders. However, the molecular and cellular mechanisms underlying the regulation …
Seven HCI grand challenges
…, W Wang, S Yamamoto, P Zaphiris, J Zhou - … Journal of Human …, 2019 - Taylor & Francis
This article aims to investigate the Grand Challenges which arise in the current and
emerging landscape of rapid technological evolution towards more intelligent interactive …
emerging landscape of rapid technological evolution towards more intelligent interactive …
Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase
…, Y Jiang, LY Huang, YB Tang, GJ Yan, JG Zhou - …, 2012 - Am Heart Assoc
Nitric oxide generated by endothelial nitric oxide synthase (eNOS) plays an important role in
maintaining cardiovascular homeostasis. Under various pathological conditions, abnormal …
maintaining cardiovascular homeostasis. Under various pathological conditions, abnormal …