A backbone-centred energy function of neural networks for protein design
A protein backbone structure is designable if a substantial number of amino acid sequences
exist that autonomously fold into it 1 , 2 . It has been suggested that the designability of …
exist that autonomously fold into it 1 , 2 . It has been suggested that the designability of …
N-terminal domain of Bombyx mori fibroin mediates the assembly of silk in response to pH decrease
YX He, NN Zhang, WF Li, N Jia, BY Chen… - Journal of molecular …, 2012 - Elsevier
Fibroins serve as the major building blocks of silk fiber. As the major component of fibroin,
the fibroin heavy chain is a considerably large protein comprising N-terminal and C-terminal …
the fibroin heavy chain is a considerably large protein comprising N-terminal and C-terminal …
Solution Structure of Human Brg1 Bromodomain and Its Specific Binding to Acetylated Histone Tails,
W Shen, C Xu, W Huang, J Zhang, JE Carlson, X Tu… - Biochemistry, 2007 - ACS Publications
Human brahma-related gene 1 (Brg1) is a core protein in human SWI/SNF chromatin-remodeling
complex which regulates gene expression. Brg1 contains a bromodomain that has …
complex which regulates gene expression. Brg1 contains a bromodomain that has …
Rotamer-free protein sequence design based on deep learning and self-consistency
Several previously proposed deep learning methods to design amino acid sequences that
autonomously fold into a given protein backbone yielded promising results in computational …
autonomously fold into a given protein backbone yielded promising results in computational …
Combinatorial readout of unmodified H3R2 and acetylated H3K14 by the tandem PHD finger of MOZ reveals a regulatory mechanism for HOXA9 transcription
Histone acetylation is a hallmark for gene transcription. As a histone acetyltransferase, MOZ
(monocytic leukemia zinc finger protein) is important for HOX gene expression as well as …
(monocytic leukemia zinc finger protein) is important for HOX gene expression as well as …
Comparison of generation 3 polyamidoamine dendrimer and generation 4 polypropylenimine dendrimer on drug loading, complex structure, release behavior, and …
N Shao, Y Su, J Hu, J Zhang, H Zhang… - International journal of …, 2011 - Taylor & Francis
Background Polyamidoamine (PAMAM) and polypropylenimine (PPI) dendrimers are the
commercially available and most widely used dendrimers in pharmaceutical sciences and …
commercially available and most widely used dendrimers in pharmaceutical sciences and …
[HTML][HTML] Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability
The de novo design of amino acid sequences to fold into desired structures is a way to reach
a more thorough understanding of how amino acid sequences encode protein structures …
a more thorough understanding of how amino acid sequences encode protein structures …
Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein
Pup (prokaryotic ubiquitin-like protein) from Mycobacterium tuberculosis is the first ubiquitin-like
protein identified in non-eukaryotic cells. Although different ubiquitin-like proteins from …
protein identified in non-eukaryotic cells. Although different ubiquitin-like proteins from …
[HTML][HTML] Structural and functional insights into the human Börjeson-Forssman-Lehmann syndrome-associated protein PHF6
The plant homeodomain finger 6 (PHF6) was originally identified as the gene mutated in the
X-linked mental retardation disorder Börjeson-Forssman-Lehmann syndrome. Mutations in …
X-linked mental retardation disorder Börjeson-Forssman-Lehmann syndrome. Mutations in …
Combined prediction and design reveals the target recognition mechanism of an intrinsically disordered protein interaction domain
…, C Wang, Y Liu, L Zhang, J Zhang… - Proceedings of the …, 2023 - National Acad Sciences
An increasing number of protein interaction domains and their targets are being found to be
intrinsically disordered proteins (IDPs). The corresponding target recognition mechanisms …
intrinsically disordered proteins (IDPs). The corresponding target recognition mechanisms …