User profiles for Jian Shu
Jian ShuMGH, Harvard Medical School, Broad Institute Verified email at broadinstitute.org Cited by 3551 |
Contact tracing assessment of COVID-19 transmission dynamics in Taiwan and risk at different exposure periods before and after symptom onset
Importance The dynamics of coronavirus disease 2019 (COVID-19) transmissibility are yet to
be fully understood. Better understanding of the transmission dynamics is important for the …
be fully understood. Better understanding of the transmission dynamics is important for the …
[HTML][HTML] Editing DNA methylation in the mammalian genome
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions of …
expression networks in many biological processes. However, investigation of the functions of …
Fluorescence imaging of pathophysiological microenvironments
Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely
associated with numerous pathophysiological processes such as inflammation, …
associated with numerous pathophysiological processes such as inflammation, …
[PDF][PDF] Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming
Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying developmental …
major challenge. Here, we introduce Waddington-OT, an approach for studying developmental …
Recent advances in photoelectrochemical sensing: from engineered photoactive materials to sensing devices and detection modes
J Shu, D Tang - Analytical chemistry, 2019 - ACS Publications
Sensing technology is one of the three pillars of information industry, which can monitor the
specific event and transform it into a readable signal according to a certain law with specific …
specific event and transform it into a readable signal according to a certain law with specific …
[HTML][HTML] Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…
Bioresponsive release system for visual fluorescence detection of carcinoembryonic antigen from mesoporous silica nanocontainers mediated optical color on …
Z Qiu, J Shu, D Tang - Analytical chemistry, 2017 - ACS Publications
An all-in-one paper-based analytical device (PAD) was successfully developed for visual
fluorescence detection of carcinoembryonic antigen (CEA) on CdTe/CdSe quantum dot (QD)-…
fluorescence detection of carcinoembryonic antigen (CEA) on CdTe/CdSe quantum dot (QD)-…
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral …
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …
[HTML][HTML] Induction of pluripotency in mouse somatic cells with lineage specifiers
The reprogramming factors that induce pluripotency have been identified primarily from
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that, …
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that, …
[PDF][PDF] Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming
…, Z Hou, X Su, B Liu, T Jiang, D Zhao, Y Sun, J Shu… - Cell stem cell, 2014 - cell.com
Obtaining fully functional cell types is a major challenge for drug discovery and regenerative
medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we …
medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we …