User profiles for Jian Shu

Jian Shu

MGH, Harvard Medical School, Broad Institute
Verified email at broadinstitute.org
Cited by 3551

Contact tracing assessment of COVID-19 transmission dynamics in Taiwan and risk at different exposure periods before and after symptom onset

HY Cheng, SW Jian, DP Liu, TC Ng… - JAMA internal …, 2020 - jamanetwork.com
Importance The dynamics of coronavirus disease 2019 (COVID-19) transmissibility are yet to
be fully understood. Better understanding of the transmission dynamics is important for the …

[HTML][HTML] Editing DNA methylation in the mammalian genome

…, H Wu, X Ji, Y Stelzer, X Wu, S Czauderna, J Shu… - Cell, 2016 - cell.com
Mammalian DNA methylation is a critical epigenetic mechanism orchestrating gene
expression networks in many biological processes. However, investigation of the functions of …

Fluorescence imaging of pathophysiological microenvironments

…, JT Hou, M Won, J An, X Chen, J Shu… - Chemical Society …, 2021 - pubs.rsc.org
Abnormal microenvironments (viscosity, polarity, pH, etc.) have been verified to be closely
associated with numerous pathophysiological processes such as inflammation, …

[PDF][PDF] Optimal-transport analysis of single-cell gene expression identifies developmental trajectories in reprogramming

G Schiebinger, J Shu, M Tabaka, B Cleary… - Cell, 2019 - cell.com
Understanding the molecular programs that guide differentiation during development is a
major challenge. Here, we introduce Waddington-OT, an approach for studying developmental …

Recent advances in photoelectrochemical sensing: from engineered photoactive materials to sensing devices and detection modes

J Shu, D Tang - Analytical chemistry, 2019 - ACS Publications
Sensing technology is one of the three pillars of information industry, which can monitor the
specific event and transform it into a readable signal according to a certain law with specific …

[HTML][HTML] Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

…, M Ansari, P Cai, B Lin, J Buchanan, S Chen, J Shu… - Nature medicine, 2021 - nature.com
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…

Bioresponsive release system for visual fluorescence detection of carcinoembryonic antigen from mesoporous silica nanocontainers mediated optical color on …

Z Qiu, J Shu, D Tang - Analytical chemistry, 2017 - ACS Publications
An all-in-one paper-based analytical device (PAD) was successfully developed for visual
fluorescence detection of carcinoembryonic antigen (CEA) on CdTe/CdSe quantum dot (QD)-…

Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral …

…, M Ansari, P Cai, B Lin, J Buchanan, S Chen, J Shu… - BioRxiv, 2020 - biorxiv.org
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, creates an urgent
need for identifying molecular mechanisms that mediate viral entry, propagation, and tissue …

[HTML][HTML] Induction of pluripotency in mouse somatic cells with lineage specifiers

J Shu, C Wu, Y Wu, Z Li, S Shao, W Zhao, X Tang… - Cell, 2013 - cell.com
The reprogramming factors that induce pluripotency have been identified primarily from
embryonic stem cell (ESC)-enriched, pluripotency-associated factors. Here, we report that, …

[PDF][PDF] Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming

…, Z Hou, X Su, B Liu, T Jiang, D Zhao, Y Sun, J Shu… - Cell stem cell, 2014 - cell.com
Obtaining fully functional cell types is a major challenge for drug discovery and regenerative
medicine. Currently, a fundamental solution to this key problem is still lacking. Here, we …